Clinical Observation Of Jieyu Huatan Decoction In The Treatment Of Generalized Anxiety Disorder (liver Depression And Phlegm Obstruction Syndrome)

Objective:To evaluate the clinical efficacy and safety of Jieyu Huatan Decoction in the treatment of generalized anxiety disorder with liver stagnation and phlegm obstruction.Methods:Sixty patients with GAD who met the diagnostic criteria were selected and randomly divided into the experimental group and the control group with 30 cases in each group.The experimental group was treated with Chinese medicine Jieyu Huatan Decoction,and the control group was treated with western medicine flupentixol meritracine(Delicin)for 4 weeks.The Hamilton Anxiety Scale(HAMA)score and TCM symptom score were observed and recorded before and after treatment in 2 groups.The scores within and between groups before and after treatment in 2 groups were statistically analyzed to evaluate the clinical efficacy of 2 groups.The safety of the two groups was evaluated by adopting TESS table as the safety index.Results:1.Jieyu Huatan Decoction can reduce the HAMA score and TCM symptom score of patients with generalized anxiety disorder.Compared with the score before treatment,the difference was statistically significant(P<0.05),the total effective rate of the two scores was 86.66%and 90.00%,respectively.2.Dalixin can reduce the HAMA score and TCM symptom score of patients with generalized anxiety disorder.Compared with the score before treatment,the difference is statistically significant(P<0.05),the total effective rate of the two scores is 83.33%and 53.33%respectively.3.There was no significant difference between Jieyu Huatan Decoction and Dailixin in improving patients’ HAMA scale scores(P>0.05),and there was a statistically significant difference between the two groups in improving TCM symptom scores(P<0.05).4.No obvious adverse reactions occurred in the treatment group and control group,indicating high safety of medication.Conclusion:Jieyu Huatan Decoction can improve the clinical symptoms of generalized anxiety disorder,and has the same efficacy as Delexin in improving HAMA scale score,but is better than Delexin in improving TCM syndromes,with low adverse reactions and high safety.In clinical practice,traditional Chinese medicine can be selected to replace western medicine according to the needs of patients and their conditions.