| Objective:Through this study,we can preliminarily observe the clinical efficacy and safety with Sangyin Tang decoction and granule in treating Children Henoch-Schonlein Purpura(Skin Type,Lung Meridian Stagnant Heat Syndrome).Methods: The patients aged from 3 to 14 years old were admitted in the affiliated hospital of chengdu university of traditional Chinese medicine from January 2019 to January 2020,and they must meet the inclusion criteria.80 cases were divided into 2 groups by using the random number table method,including 40 cases in the test group and 40 cases in the control group.Under the premise of basic western medicine treatment in both groups,the test group was combined with Sangyin Tang granules and the control group was combined with Sangyin Tang decoction.The observation period is 2 weeks.The data were collected on weeks 0,1 and 2 and analyzed.After the observation period,we would follow up the recurrence within 4 weeks.Results:(1)1 case was lost after the experiment,79 cases were finished and analyzed.(1)In this trial,the average age was 7.66 years old.And there were no obvious significant differences in the gender and age distribution between the two groups of children(P>0.05).That means the two groups were comparable.(1)There was no statistical difference in the distribution of various symptom scores and total scores before treatment between the two groups(P> 0.05).We can know that the two groups are comparable.(1)The comparison between the control group and the test group before and after treatment had obvious effects on improving the primary and secondary symptoms of the children(P <0.01).(1)Comparison between the two groups after treatment: There was no statistically significant difference between the two groups in improving the primary and secondary syndrome scores(P> 0.05).(1)Comparison of efficacy evaluation: The recovery rate of the control group was 72.5.6%,which was higher than the 71.8% of the test group,but the difference was not statistically significant(P <0.05).(1)Comparison of rash recurrence rate: 4 weeks after drug withdrawal,the rash recurrence rate in the control group was 7.5%,and the rash recurrence rate in the test group was 5.4%,the difference was not statistically significant(P> 0.05),suggesting that two different dosage forms were used to prevent rash and there was no significant difference in relapse.(1)Safety evaluation: No adverse reactions occurred during treatment in both groups.Conclusion: Both groups have improved significantly,and there is no significant difference in the efficacy of the two dosage forms,and both groups are safe.The therapeutic effect of granule and decoction is equivalent,suggesting that granule have clinical application value. |
