Measurement Of Choroidal Thickness In Children And Adolescents Using EDI-OCT

Purpose:Research progress in measuring the choroid thickness.Using depth enhanced imaging OCT and combining with OCT system graphic analysis software to scan images.Measurement and analysis of choroidal thickness in normal children and adolescents.Methods:Twenty healthy volunteers(40 eyes)were randomly recruited.The choroidal images of healthy volunteers obtained by OCT-EDI(Heidelberg)mode were as the verification group.The anterior choroidal boundary(Bruch membrane)was automatically generated by Heidelberg software.At the same time,the posterior choroidal boundary was manually depicted with the drawing tool in OCT system to make the choroidal contour.A program was written to calculate choroidal thickness to verify the repeatability of the method.From January,2020 to March,2020,the OCT images of 99 children and adolescents aged 7-18 were collected from the First Affiliated Hospital of Zhejiang University Medical College.A total of 198 eyes were taken as the experimental group.The choroidal thickness of the experimental group was measured by the method previously verified.Result:1.ICC was 0.975,95% CI was [0.959,0.984],p=0.000.2.The average thickness of choroid in horizontal direction is 241.07±65.37?m in 5mm range,and it was 259.65±66.14?m in the vertical direction.The correlation coefficients of choroidal thickness and axial length in horizontal and vertical directions were-0.642,-0.624(p=0.000,p= 0.000).The correlation coefficients between choroid thickness and diopter in horizontal and vertical directions were 0.610,0.583(p=0.000,p=0.000).The correlation coefficients between choroid thickness and age is-0.293 and-0.281 in horizonal and vertical direction respectively.Conclusion:1.The experimental method has good repeatability and can calculate the average thickness of choroid from each pixel.2.The choroidal thickness of vertical direction in children and teenagers was greater than that of horizonal direction.3.There was weakly significant correlation between choroidal thickness and age,but significant with axial length and diopter.4.The most significant factor of predictor of choroidal thickness in 7-18-years old subjects is axial.