| Objective:The implicit association test?IAT?was used to detect the event-related potentials?ERPs?of implicit cognitive tasks in alcohol-related picture information in patients with alcohol dependence and healthy controls.And to explore the characteristics of ERPs of implicit cognitive bias in patients with alcohol dependence,so as to provide objective basis for the pathogenesis and intervention of alcohol dependence.Methods:30 adult male patients who met the diagnostic criteria of"alcohol dependence"in the Diagnostic and Statistical Manual of Mental Disorders in the United States?Fifth Edition??DSM-5?were selected,and 30 cases of normal health matched with sex,age and education level were selected as the normal control group.All subjects were tested with implicit cognitive task test?IAT?,based on picture-attitude response,in which pictures were divided into two categories:alcohol-related and alcohol-independent,and attitude words were positive vocabulary and negative vocabulary.The electroencephalogram?EEG?activity of the subjects was recorded synchronously during the detection of IAT.Comparison:?1?The difference of reaction time between the study group and the control group under different types of picture-attitude word pairs;?2?The ERPs indexes?N2,P3,N4 components?of different types of picture-attitude word pairs between the study group and the control group.Results:?1?Comparison of behavioral data between study group and control groupThe interaction between picture type and attitude word in the study group was significant[F?1,29?=32.08,P=0.003].The reaction time to alcohol related picture-positive attitude word and alcohol-independent picture-negative attitude word[?653.2±42.3?ms,?698.5±38.1?ms]were shorter than that of alcohol-unrelated picture-positive attitude word[?680.2±40.1?ms]and alcohol-related picture-negative attitude word[?713.3±43.3?ms][F?1,29?=28.08,37.06,P=0.002,0.000].The main effect of picture type and attitude words in the study group was significant[F?1,29?=37.88,43.08,P=0.004,0.002].The reaction time to alcohol-related pictures was shorter than that to alcohol-related pictures.The reaction time to alcohol-related picture-positive attitude words in the study group was significantly faster than that in the control group[?710.0±32.3?ms]?P=0.009?.?2?Analysis of ERPs data of implicit associative test between study group and control group1)N2 ingredients:The N2 latency,amplitude at different electrode sites and lateral interaction or effect between picture type?alcohol-related picture,alcohol-independent picture?and attitude words?positive attitude,negative attitude?were not significant[F?1,29?=3.79?6.32,P>0.05]in the study group and the control group.2)P3 ingredients:there was significant interaction between picture type and P3amplitude of attitude words in the study group[F?1,29?=24.34,P=0.003].The P3amplitude of alcohol-related picture-positive attitude word was significantly higher than that of alcohol-related picture-negative attitude word[F?1,29?=8.87,P=0.030].The P3 amplitude of alcohol-independent picture-negative attitude word was significantly higher than that of alcohol-unrelated picture-positive attitude word[F?1,29?=7.63,P=0.028].There was interaction between picture type,attitude word and electrode site[F?4,116?=11.20,P=0.001].There was significant interaction between picture type and attitude word at frontal,frontal-midline and midline electrode sites[F?1,29?=17.20,21.78,19.67,P=0.008,0.001,0.021].3)N4 ingredients:the N4 latency,amplitude at different electrode sites and lateral interaction or effect between picture type?alcohol-related picture,alcohol-independent picture?and attitude words?positive attitude,negative attitude?were not significant[F?1,29?=4.60?6.88,P=0.123?0.195]in the study group and the control group.Conclusions:?1?Patients with alcohol dependence have an attention bias to alcohol-related picture information.?2?The implicit cognitive bias of alcohol-related information in alcohol-dependent patients may be related to changes of cerebral cortex function in the forehead and midline. |
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