Study On Related Factors Of Atrophic Glossitis In Qingdao

Objective: To explore the relationship between atrophic glossitis(AG)in Qingdao population and anemia(including pathological types of anemia and anemia-associated factors),oral candidiasis,xerostomia.Methods: 124 cases of atrophic glossitis and 53 cases of healthy control in Qingdao population were enrolled in this research.Complete blood count(CBC),anemia-associated factors(including vitamin B12,ferritin,folic acid),and oral candida smear microscopy were conducted.In addition,Sj?gren's syndrome related tests were carried out in patients accompanied with xerostomia.The data on CBC,vitamin B12,ferritin,folic acid,anemia and its pathological types,xerostomia,and oral candidiasis were statistically analyzed using SPSS 20.0 software package.According to hemoglobin(Hb),mean corpuscular volume(MCV),Mean Corpuscular Hemoglobin Concentration(MCHC),patients with atrophic glossitis were classified into three anemia types including microcytic group(MCV < 80fL),macrocytic group(MCV ? 100fL)and normocytic group(MCV 80-99.9fL).LSD-t test was performed to compare the statistical difference of the Hb,MCV,vitamin B12,ferritin and folic acid between the case groups and control group.Chi-square test was performed in terms of the presence of Candida in microscopy and the presence of xerostomia in both AG group and control group.Results:(1)Among the AG group,the number of patients accompanied with anemia was 60,accounting for 48.39%,which consist of 24 cases of macrocytic anemia(19.35%),20 cases of microcytic hypochromic anemia(16.13%),and 16 cases of normocytic anemia(12.90%).The number of patients concomitant with xerostomia was 52(41.94%),among which 11(21.15%)were diagnosed as Sj?gren's syndrome.The number of patients infected with candida was 98(79.03%).(2)The number of AG patients along with vitamin B12 deficiency was 36(29.03%)included 17 cases of macrocytic anemia,11 cases of megaloblastic erythroid changes,3 cases of normocytic anemia,3 cases of normal CBC,and 2 cases of microcytic hypochromic anemia with ferritin deficiency.The number of AG patients along with ferritin deficiency was 28(22.58%)included 22 cases of microcytic hypochromic anemia,5 cases of normocytic anemia,and merely 1 case of normal Hb and lower-than-normal MCV.Among 14 cases(11.29%)of AG patients with folic acid deficiency,not a single case presented with macrocytic anemia was found.(3)The number of patients with anemia,xerostomia and candidiasis in AG group is significantly higher than that of control group.(P <0.05).Conclusion: The occurrence of atrophic glossitis in Qingdao population is closely related to anemia and anemia types,anemia-associated factors(vitamin B12 deficiency,ferritin deficiency),xerostomia,and oral candidiasis,and no significant correlation with folic acid deficiency was confirmed.In regard to the pathological types of anemia,the proportion of macrocytic anemia accounts for the largest among AG patients,followed by microcytic hypochromic anemia,normocytic anemia.Among those anemia-associated factors we examined,vitamin B12 deficiency ranked the first,following by ferritin deficiency,and folic acid deficiency.CBC,anemia-associated factors(vitamin B12 and ferritin),oral candida smear microscopy,and related tests targeted at Sj?gren's syndrome on patients with xerostomia can be put in practice in clinical medicine,which are conducive to the etiological exploration and treatment of atrophic glossitis.