TCM Syndrome Type And Clinical Characteristics Of Patients With Polycystic Ovary Syndrome And Infertility

Objective:Through statistical analysis of clinical characteristics of PCOS and infertility patients with different TCM syndromes,the aim was to objectively guide the clinical treatment and improve the pregnancy status of these patients.Methods:Screen out the patients with PCOS and infertility in the Depsrtment of gynaecology of the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine from January 2014 to December 2019 and finally 384 integral cases were collected.According to the TCM syndrome grading scale,these patients were divided into spleen deficiency phlegm dampness syndrome,kidney deficiency liver depression syndrome,kidney deficiency blood stasis syndrome and phlegm stasis syndrome.By using SPSS 21.0,the distribution and clinical characteristics of the four syndromes were analyzed.Results:1.The distribution of the TCM Syndrome Type in PCOS and infeirility was 33.3%(128 cases)with kidney deficiency liver depression syndrome,3 1.0%(119cases)with phlegm stasis syndrome,20.3%(78cases)with spleen deficiency phlegm dampness syndrome and 15.4%(59cases)with kidney deficiency blood stasis syndrome.The difference of frequency distribution was statistically significant(P<0.05)2.In general information,the infertility year in patients with kidney deficiency blood stasis syndrome and phlegm stasis syndrome was higher than those with spleen deficiency phlegm dampness syndrome and kidney deficiency liver depression syndrome.The incidence of seborrhoea in the patients with pleen deficiency phlegm dampness syndrome and phlegm stasis syndrome was higher than those with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome,as well as the value of systolic blood pressure?body weight WC?HC?WHR?hiesutism score and black spiny skin score.The value of diastolic pressure in patients with phlegm stasis syndrome was higher than those with kidney deficiency blood stasis syndrome.The value of WC and HC in patients with kidney deficiency blood stasis syndrome were higher than those with kidney deficiency blood stasis syndrome while the hairy score is lower.The acne score in patients with kidney deficiency liver depression syndrome was lower than those with the other three syndromes.The above differences were statistically significant(P<0.05)3.In sex hormone metabolism,the value of LH?SHBG and LH/FSH of the patients with pleen deficiency phlegm dampness syndrome and phlegm stasis syndrome were lower than those with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome.The differences were statistically significant(P<0.05)4.In glycolipids and insulin metabolism,there were a higher value of G30'?G60'?G120'?HOMA-IR?F60'?F180'?TG and APOB in the patients with spleen deficiency phlegm dampness syndrome and phlegm stasis syndrome than those with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome.The value of FPG in patients with spleen deficiency phlegm dampness syndrome was higher than those with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome.The value of F120,in patients with spleen deficiency phlegm dampness syndrome and phlegm stasis syndrome was higher than those with kidney deficiency blood stasis syndrome.The value of APOB/A and LP(a)in patients with spleen deficiency phlegm dampness syndrome were higher than those with kidney deficiency liver depression syndrome.The above differences were statistically significant(P<0.05)5.In the incidence of metabolic diseases,there was a higher incidence of NGT in patients with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome than those with spleen deficiency phlegm dampness syndrome.The incidence of IGT in patients with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome was higher than those with spleen deficiency phlegm dampness syndrome.The incidence of IR?T2DM and MS in the patients with spleen deficiency phlegm dampness syndrome and phlegm stasis syndrome were higher than those with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome.Moreover,the incidence of MS in patients with kidney deficiency liver depression syndrome was higher than those with kidney deficiency blood stasis syndrome.The above differences were statistically significant(P<0.05)Conclusions:1.Kidney deficiency liver depression syndrome and phlegm stasis syndrome are main TCM syndromes of PCOS and infertility patients2.Phlegm stasis syndrome has the longest infertility period most obviously from 5 to 10 years3.In clinic,compared to the PCOS and infertility patients with kidney deficiency liver depression syndrome and kidney deficiency blood stasis syndrome,we should consciously pay attention to the negative effects caused by the higher level of BMI and incidence of black echinoderm?more obvious disorder signs of sex hormones and glucose and lipid metabolism and higher incidence of metabolic diseases such as T2DM and MS among the spleen deficiency phlegm dampness syndrome and phlegm stasis syndrome.