Effect Of Helicobacter Pylori Infection On Blood Pressure And Some Serum Biochemical Indexes

Objective:1.To investigate the effect of Helicobacter pylori infection on blood pressure and some serum biochemical indexes;2.To explore the correlation between Helicobacter pylori infection and essential hypertension.Methods:From May 2018 to December 2019,100 patients with primary hypertension confirmed in Affiliated Hospital of Yan'an University were selected as the hypertension group and 100 healthy people as the control group.The subjects in the two groups were given carbon 14 breath test,24-hour ambulatory blood pressure monitoring and blood sampling test biochemical indicators(including C-reactive protein,homocysteine,triglyceride,total cholesterol,high-density lipoprotein,low-density lipoprotein and fasting plasma glucose,etc.)on an empty stomach in the morning.The positive rate of H.pylori in hypertension group and control group were calculated and compared;The patients in hypertension group were divided into 1,2 and 3 grades according to the standard of Chinese hypertension prevention and control guideline(2010 version)(hypertension grade was divided according to the blood pressure level under the control of the original treatment plan),and the positive rates of HP in different grades of hypertension were compared;The biochemical indexes of hypertension group and control group were compared;The data of the hypertension group were divided into positive and negative groups according to the results of H.pylori,and the biochemical indexes were compared;All patients with H.pylori positive were treated with standard quadruple therapy(esomeprazole magnesium enteric coated tablets 20 mg bid+amoxicillin capsules 1g bid + clarithromycin sustained-release tablets 0.5g Bid+colloidal bismuth pectin granules 0.3g bid)for 2 weeks,and then were given carbon 14 breath test,24-hour ambulatory blood pressure monitoring and biochemical indexes of blood sampling test after 4 weeks of drug withdrawal.Compared with the indexes before treatment.Through the above study,to investigate the effect of Helicobacter pylori infection on blood pressure and some serum biochemical indexes,and whether there is a correlation between H.pylori infection and essential hypertension.SPSS 19.0 statistical software was used for data analysis,all data were tested for normality and homogeneity of variance,measurement data were expressed by mean ± standard deviation,t test was used for comparison between two groups,and single factor analysis of variance was used for multiple groups,count data was expressed by rate,and chi square test was used for comparison of rate,P<0.05 was statistically significant.Results:1.A total of 89 patients were positive for H.pylori.The total positive rate of H.pylori was 44.5%.The positive rate of H.pylori in the hypertension group(52%)was higher than that in the control group(37%).The difference between the two groups was statistically significant.2.There were 45 patients with grade 1 hypertension,23 of them were HP positive,the positive rate was 51.1%;there were 23 patients with grade 2 hypertension,12 of them were HP positive,the positive rate was 52.2%;there were 32 patients with grade 3hypertension,17 of them were HP positive,the positive rate was 53.1%.There was no significant difference in the positive rate of HP in different grades of hypertension in the hypertension group(? 2=0.031,P>0.05);3.In the hypertension group,on the basis of the original antihypertensive therapy,the HP positive patients were treated with standard quadruple therapy.Among them,52 cases were HP positive and 50 cases were successfully eradicated.The difference of blood pressure before and after Hp eradication was statistically significant.4.The levels of FPG,CRP,Hcy,TG and TC in the hypertension group were higher than those in the control group,but there was no significant difference in HDL and LDLbetween the two groups.5.The levels of SBP,DBP,FPG,CRP,Hcy,TG and TC in HP positive group were higher than those in HP negative group,but there was no significant difference in HDL and LDL between the two groups.6.All HP positive patients were treated with standard quadruple therapy.There were89 HP positive cases,79 of them successfully eradicated HP,and the eradication rate was about 88.8%.In the hypertension group,50 cases were successfully eradicated,2 cases failed to be eradicated;in the control group,29 cases were successfully eradicated,8cases failed to be eradicated.6.1 The levels of FPG,CRP,Hcy,TG and TC in hypertension group after HP successfully eradication were lower than those before treatment,the difference was statistically significant,but the changes of HDL and LDL before and after treatment were not significant.6.2 There was no significant difference in FPG,CRP,Hcy,TG,TC,HDL and LDL levels before and after HP eradication in the control group.6.3 The levels of FPG,CRP,Hcy,TG and TC in HP positive patients after Hp successfully eradication were lower than those before treatment,the difference was statistically significant,but the changes of HDL and LDL before and after treatment were not significant.6.4 The levels of FPG,CRP,Hcy,TG,TC,HDL and LDL in HP positive patients were not significantly different from those before treatment.Conclusions:1.Helicobacter pylori infection may increase the level of blood pressure.2.Helicobacter pylori infection may increase the level of C-reactive protein,triglyceride,total cholesterol,homocysteine and fasting plasma glucose.3.Helicobacter pylori infection may promote the occurrence of essential hypertension through the influence of C-reactive protein,triglyceride,total cholesterol,homocysteine and fasting plasma glucose.4.Eradication of Helicobacter pylori may provide new ideas and effective measures for the prevention and treatment of essential hypertension and other diseases,so as to further reduce the incidence of cardiovascular and cerebrovascular diseases.