Correlation Between Helicobacter Pylori Genotypes And High Homocysteine

Objective:To explore the association between different genotypes of Helicobacter pylori and coronary heart disease by detecting the plasma levels of homocysteine (HCY) and High-sensitivity C-reactive protein (hs-CRP) in patients with coronary heart disease.Methods:Select the line in our hospital endoscopy were divided into CHD and non-CHD group (control group) 60 cases. Recorded before gastroscopy patient name, sex, age, height, weight, blood pressure, smoking, and fasting venous blood for biochemical testing, measurement of homocysteine, lipids, glucose, fibrinogen (Fib), High-sensitivity C-reactive protein (hs-CRP), endoscopic gastric tissue obtained, stained with toluidine blue line method to measure HP, HP positive on fluorescence in situ hybridization further detected cagA gene.Results:1. CHD group was significantly higher HP infection rate of HP infection (55% vs 30%, P<0.01), the difference was statistically significant.2. CHD group, plasma HCY levels of HP-positive patients was significantly higher than HP negative patients (17.9±3.08 vs 13.13±4.08, P<0.01), the difference was statistically significant.3. HP-positive patients with coronary heart disease group, the cagA gene detection rate was higher in HP positive patients (60.6% vs 27.8%, P<0.025), the difference was significant; cagA genotype plasma HCY levels were significantly higher than the non-cagA genotype (21.19±4.69 vs 15.80±2.79, P<0.001), the difference was statistically significant.4. In terms of coronary heart disease group or the control group, cagA genotype and blood pressure in patients with non-cagA genotype, sex, smoking status, age, obesity, blood lipids, blood glucose, fibrinogen level of the difference was not statistically significance (P all> 0.05); both coronary heart disease or control group, cagA genotypes in patients with non-plasma hs-CRP levels in patients with cagA genotypes, the differences were statistically significant (P all<0.05).Conclusion:1.Helicobacter pylori infection and coronary heart disease occurrence and development is closely related to, HP-positive patients was significantly higher than plasma HCY levels of HP-negative patients, Hp infection may be by influencing the level of plasma HCY play in coronary heart disease a role. HP-positive infections in patients, cagA genotype was significantly higher than the plasma HCY levels in patients with non-cagA genotype may be infected with cagA genotypes of HP patients, through increased levels of plasma HCY induced the middle part of the occurrence of atherosclerosis, development.2. Different genotypes of Helicobacter pylori with the traditional factors (gender, smoking, age, blood pressure, obesity, blood lipids, blood glucose, fibrinogen) no significant correlation. HP infection in patients with cagA genotype C-reactive protein level was significantly higher than that of HP infection in patients with non-cagA genotype may be infected with cagA-type Hp patients, the increased plasma concentration of C-reactive protein, and then in coronary atherosclerosis.