Clinical Study On Influencing Factors Of Recurrence After Radical Resection Of Cervical Cancer

Objective:Through a retrospective survey from January 2012 to January 2015,radical cervical surgery was performed at the Third and Fourth Affiliated Hospitals of Kunming Medical University(extensive whole uterus+pelvic lymph node dissection± double appendectomy+para-aortic lymph node Sampling biopsy)Survival of the patient after operation,statistics of the five-year recurrence rate of the patient,at the same time investigating the patient's surgical method(laparoscopy or laparotomy),age distribution,lymph node metastasis,pathological classification,postoperative complications and other factors.The impact of the patient's prognosis.Methods:1.Selected from January 2012 to January 2015 at the Third and Fourth Affiliated Hospitals of Kunming Medical University for cervical cancer radical surgery(extensive total uterus+pelvic lymph node dissection±double appendectomy+para-aortic lymph node sampling biopsy)),according to the 2009 edition of FIGO stage,the stage is Ia2,Ib1,Ib2,Ib2,IIal,IIa2,IIb.Follow-up was conducted through inpatient review,outpatient review,and telephone follow-up.Statistic patient information and summarize data.Statistical items include:patient age,BMI,surgical method,disease stage,pathological classification,presence or absence of lymph node metastasis,and recurrence.Analyze the influence of the above factors on the prognosis of patients.2.In this study,all data were applied to WPS work statistics and SPSS 22.0 software was used for data analysis.The measurement data was expressed as mean±standard deviation,single factor analysis was performed using chi-square test and Kapla-Meier survival analysis,and multiple linear stepwise regression analysis was used for statistically significant single factor.The test value ?=0.05,with P<0.05 as the difference has statistical significance,P<0.01 as the significant difference.Results:1 Single factor analysis of recurrence after cervical cancer surgery1.1 The five-year survival rate of cervical cancer patients is 85.9%,and the five-year recurrence rate is 18.3%1.2 Cervical cancer patients with pelvic lymph node metastasis had higher recurrence rate after surgery than patients without pelvic lymph node metastasis,and the greater the number of lymph node metastases,the higher the recurrence rate,2=9.220,P=0.003.1.3 Among patients with cervical cancer surgery(stage Ia2-stage IIb),the postoperative recurrence rate of patients with FIGO stage Ib2 and stage IIa2 is higher than that of other stages,?2=27.964,P=0.000.1.4 Among patients with cervical cancer,patients with muscular layer infiltration depth?1/2 have higher recurrence rate after operation than patients with muscular layer invasion<1/2,?2=13.438,P=0.000.1.5 Among patients with cervical cancer,the recurrence rate of newly treated patients with tumor diameter?4 cm is higher than that of newly treated patients with tumor diameter<4 cm,x2=53.658,P=0.000.1.6 Among cervical cancer patients,the postoperative recurrence rate of patients with HPV not negative after surgery is higher than that of patients with postoperative HPV negative,?2=4.017,P=0.045.1.7 Among cervical cancer patients,the age,BMI,surgical method(opening,laparoscopy),whether to remove the ovary,pathological type,degree of differentiation and other factors have no significant effect on the postoperative recurrence rate.2 Multifactor analysis of recurrence of cervical cancer after operationMultiple linear stepwise regression analysis of cervical cancer patients showed that FIGO stage,depth of muscular invasion,diameter of newly treated tumor,and whether pelvic lymph node metastasis were all independent risk factors for postoperative recurrence of cervical cancer patients(P<0.05).Conclusion(s):1.Whether cervical cancer patients have pelvic lymph node metastasis,FIGO stage,depth of muscular invasion,diameter of newly treated tumor,and whether HPV turns negative after surgery are all risk factors for recurrence of cervical cancer after surgery.2.Pel vic lymph node metastasis,FIGO stage,depth of muscular invasion,and initial tumor diameter are independent risk factors for recurrence of cervical cancer.3.Although the degree of differentiation of patients with cervical cancer has no statistically significant difference in the recurrence of patients after surgery,the recurrence rate of patients in the poorly differentiated group is significantly higher than that in the moderately differentiated group and the highly differentiated group.