Risk Factors And Intervention Study Of Patients With Nonalcoholic Fatty Liver Disease In A General Hospital In Urumqi City

Objective: NAFLD is the liver disease with the highest prevalence at present,providing scientific basis for early prevention of NAFLD and prevention and control of cardiovascular disease by understanding the prevalence of NAFLD and related risk factors in the physical examination population of a third-class first-class hospital in Urumqi,Xinjiang.Currently,improving diet is the most commonly used intervention for NAFLD.The improvement of NAFLD and its traditional cardiovascular risk factors in patients with NAFLD was investigated through a 6-month dietary intervention for NALFD patients.Methods: A total of 2886 participants who underwent physical examination in the first affiliated hospital of Xinjiang Medical University from January to June 2019 were enrolled.Record the patient's general clinical data and laboratory examination indicators.Among them,27 patients with NAFLD were willing to participate in the intervention study of nutritional outpatient dietary guidance,and were re-examined after 6 months of intervention.Statistical processing: all data were processed by SPSS 24.0 statistical software.Results:(1)As the increase of BMI,the prevalence of NAFLD increased.The prevalence of NAFLD in normal weight people was 8.39%,and that in overweight people was 26.66%.The prevalence of NAFLD in obese population was 44.55%,and the differences between groups were statistically significant(P<0.05).(2)In addition to the common characteristics of increased BMI,abnormal blood lipid and blood glucose metabolism were found in non-obese and overweight NAFLD patients.Overweight and obese women were more likely to develop NAFLD.Non-obese NAFLD people are more likely to have dyslipidemia.(3)There were gender differences in the incidence of NAFLD,and women,BMI,TG and LDL were the main risk factors for NAFLD(P <0.05).(4)Compared with non-NAFLD population,NAFLD patients generally had abnormal lipid metabolism,and the difference in the detection rate of abnormal lipid metabolism was statistically significant(P<0.05).(5)Compared with non-NAFLD population,NAFLD patients had a higher detection rate of traditional cardiovascular disease risk factors,with statistically significant differences(P < 0.05).(6)Multinomial logistic regression analysis showed that smoking,hypertension and LDL abnormalities were the major risk factors for carotid intima thickening and plaque formation in NAFLD(P<0.05).(7)After weight loss intervention for NAFLD,SBP,DBP,UA,TC,TG,LDL,ALT,AST and AI all decreased,while HDL increased.The difference before and after intervention was statistically significant(P<0.05).(8)After intervention,the detection rate of traditional cardiovascular risk factors in NAFLD patients decreased,with statistically significant differences(P<0.05).Conclusions: In the population,the prevalence of NAFLD increases with the increase of BMI.Even in normal body weight,vigilance should be enhanced to screen for NAFLD.The metabolic characteristics of NAFLD were different in different body weight groups.Dyslipidemia is a risk factor for NAFLD.Patients with NAFLD are often accompanied by dyslipidemia.Therefore,patients with dyslipidemia are also screened for NAFLD.The high detection rate of traditional cardiovascular risk factors in NAFLD patients suggests that traditional cardiovascular risk factors should be screened in NAFLD patients.Dietary interventions can reduce the risk of traditional cardiovascular disease in NAFLD patients and can be promoted in appropriate populations.