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Hong Kong Non-alcoholic Fatty Liver Disease Risk Factors And Syndromes The Law

Posted on:2010-10-26Degree:MasterType:Thesis
Country:ChinaCandidate:W D CaiFull Text:PDF
GTID:2204360272994746Subject:TCM clinical basis
Abstract/Summary:PDF Full Text Request
Non-alcoholic fatty liver disease(NAFLD) is fatty inflammation (steatohepatitis) and scarring(steatonecrosis) of the liver caused by an accumulation of fat deposits in the liver tissue when this is not due to excessive alcohol use.The NAFLD is a kind of disease due to imbalance liver metabolic syndrome,resulting excessive fat deposits pathology. Fatty liver disease is not found in ancestor Chinese Medicine.According to its pathology and clinical manifestation,fatty liver disease should fall into Chinese Medicine categories of "accumulation","blood stasis", "chest pain" and "sputum",NAFLD is an extremely common medical condition with a kind of high morbidity disease.This paper discussed the several factors relationg to the onset of NAFLD,with respect to the revisiting of the theoretical principles and the statistical analysis of the clinical data being collected.Theoretical studiesThe project aimed to redefine the definition for NAFLD as well as to put the observed symptoms into several specific classifications.This project not only recapped the common methods currently used in clinical diagnosis,but also provided updates of the active progress in the present epidemiological research.The project focused on discussion of the existing groups of traditional symptom complexes,as well as the ability to identify these complexes using the diagnostic methods in traditional Chinese medicine.The great importance of dietary preferences of victims,in triggering the onset of NAFLD,was also highlighted.Upon this,it was then possible to summarize the various commonly encountered symptom complexes of NAFLD,applying the principles applied in TCM diagnostics.The explanation of the findings also integrated the knowledge of both the basic principles in TCM and those of modern nutritional studies.Thus,this study not only aided the accuracy in clinical diagnosis at the point of onset of the illness,but also provided significant scientific evidence for future clinical research and development.This has unknowingly open doors to prevention medicine and its related clinical treatments for NAFLD.Clinical studies1.The identification of life-threatening genes in NAFLD sufferers150 related clinical case studies were collected and analyzed,using the diagnostic standards as reference for diagnosing NAFLD.The aim of this part of the project was to investigate the factors which might play a crucial role in triggering NAFLD,which included genders,age and obesity of the sufferers.In general,the findings showed that individuals between 40 to 50 years old made up the biggest proportion,standing at 39%from all the cases observed.Furthermore,obesity related NAFLD occupied 70%in the 150 cases.Obese patients having different level of NAFLD always come with hyperlipaemia or high blood content triglyceride. 2.The study of distinctive symptoms and specific characteristics of symptom complexes in diagnosing NAFLD.A list of the common distinctive symptoms was put together using the outbreak frequencies done in the statistical analysis for NAFLD. Evaluation tests were then carried out for each case study by a Hong Kong Registered Chinese Medicine Practitioner,to filter out the viability of the several different common symptom complexes observed.The results showed that the most common symptom complexes are "sputum and blood stasis","congested live and weak spleen","damp and heat", "gas stasis and blood stasis" and "deficiency of liver and kidney".The analysis for the study of distinctive symptoms and specific characteristics of symptom complexes are aligned with most Chinese medicine practitioners.It is believed that the malfunctioning of liver and spleen,sputum,blood stasis,damp and heat all contributes to formation of liver meridian congestion of "sputum and blood stasis".Liver originated and imbalance of spleen and kidney are main pathogenesis of NAFLD.3.The investigation of dietary preferences in NAFLDFurther studies were carried out to investigate the effects of dietary preferences had on NAFLD.Several dietary patterns unique to each common symptom complex were also explored using the TCM diagnostic skills.Combining the theoretical and clinical findings,both the tested groups and control groups(150 samples were observed for each group) were closely studied and compared.It was found that there were three distinctive dietary preferences which were commonly seen in victims of NAFLD.This included specified preferences to a) food of coldor warm-natural properties,b) diets of mixed or solely vegetarian orientation,and c) food with different amounts of proteins and fats.With the introduction of the principles and measuring methods applicable to modern nutritional studies,there were several types of dietary conditions which were found to be closely associated with NAFLD and its related symptom complexes.The results showed that those individuals,who had a strong preference in food of low-protein contents,exhibited no tendencies in NAFLD,at a rate of 13.33%.While those who preferred food with high fat-contents stood out at a proportion of only 85.33%.The result was significant after comparing with the control groups.In addition, it was found that cold-nature diet patients occupying 43.93%"sputum and blood stasis" symptom complex.It was also found that 30.23%of the overall cases were classified under the "damp and heat" symptom complex for individuals who preferred warm-nature diets.It indirectly proved that Chinese medicine diagnosis has its scientific basis in questioning the preferred ware and cold nature diets.
Keywords/Search Tags:Non-alcoholic fatty liver disease (NAFLD), sign complexes, symptom complexes, dietary preferences
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