The Relevant Risk Factors Of Non-alcoholic Fatty Liver Disease And It’s Relationship With Metabolic Syndrome

Objective: To survey the clinical characteristics of patients with non-alcoholic fatty liver disease(NAFLD) and Metabolic Syndrome(MS). To analyze the relationship between NAFLD and MSand its components, investigate the risk factors of NAFLD. To explore the contribution of riskfactors that lead to NAFLD, in order to facilitate clinicians to take early interventions.Object and Methods: A total of127NAFLD patients were divided into mild NAFLDgroup(n=61), moderate NAFLD group(n=45), and severe NAFLD group(n=21) according to theseverity of hepatic steatosis evaluated by color Doppler ultrasound,21patients without NAFLDwho visit the hospital during the same period were selected as a control group. All objects wereexamined by special professionals to measure the body height, body weight, waist circumference,blood pressure, underwent liver ultrasound, hepatic function, fasting plasma glucose, blood fat,markers of Hepatitis B virus and Hepatitis C virus, and received abdominal CT scans to determinevisceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT).Results:1. The proportion of control group and NAFLD group with obesity were respectively19.0%,44.3%,64.4%,71.4%, the difference was statistical significance（χ~2=16.440, P=0.001）.The proportion of control group and NAFLD group with abdominal obesity were respectively38.1%,85.2%,97.8%,95.2%, The difference was statistical significance（χ~2=32.516, P<0.001）.2.The severity of NAFLD was positively correlated with BMI, WC, VAT（r=0.467,P<0.001; r=0.503, P<0.001; r=0.473, P<0.001）, Logistic regression Analysis showed that WC（OR=10.077, P<0.001,95%C.I.=3.109~32.660）, VAT（OR=2.031, P<0.05,95%C.I.=1.026~4.023）were the risk factors of NAFLD.3.There were significant differences in FBG of control group and NAFLD groups (P<0.0167for all comparisons), The severity of NAFLD was positively correlated with FBG(r=0.369,P<0.001), Logistic regression analysis showed that FBG(OR=2.402, P=0.058,95%C.I.=0.970~5.948) was the risk factor of NAFLD.4.The proportion the control group and NAFLD groups with metabolic syndrome wererespectively14.3%,45.9%,71.1%,71.4%, The difference was statistical significance(P<0.001).Three groups of NAFLD were significantly higher than the control group, the differences werestatistical significance(P<0.0167for all comparisons). The severity of NAFLD was positivelycorrelated with TG、FBG、SBP、DBP (r=0.386, P<0.001; r=0.369, P<0.001; r=0.279,P<0.001; r=0.295, P<0.001); The severity of NAFLD was negatively correlated withHDL-C(r=-0.209, P=0.011).Conclusions: In NAFLD group with obesity and abdominal obesity, a higher proportion. WC、VAT、FBG are risk factors of NAFLD, and HDL-C may be the protect factorsof it. There was a high proportion of MS in NAFLD patients, VAT≥100cm2, namely visceralobesity significantly increased the proportion of MS. With the intensifying of fatty degeneration,the proportion of MS also increased. The severity of NAFLD was positively correlated withmetabolic syndrome’s components.