Retrospective Analysis Of The Clinical Effect Of 62 Patients With Stage ? Diabetic Nephropathy

Objective:Through the retrospective analysis of the clinical data of 62 patients with DKD,observe the clinical effect of TCM syndrome differentiation and treatment of DKD,use the auxiliary platform system of TCM inheritance to summarize the rules of prescription and medication of Professor Zhang Peiqing's syndrome differentiation and treatment of DKD(phase III and IV),so as to provide effective prescription for clinical treatment of DKD.Method:The clinical data of 62 patients with DKD(stage ?)and a course of more than 6 months were collected from January 2018 to January 2020 in the outpatient and inpatient department of the second and eighth departments of kidney,Heilongjiang University of traditional Chinese medicine.All the patients were counted and a complete database was established.SPSS 25.0 was used to observe the changes of clinical symptoms,laboratory indexes and clinical efficacy.Using the system of traditional Chinese medicine auxiliary inheritance platform to summarize and sort out,this paper analyzes the rules of prescriptions and drugs of TCM syndrome differentiation and treatment prescriptions of Professor Zhang Peiqing in treating DKD.Result:After 24 hours of treatment,the amount of urine protein was significantly lower than that before treatment,the difference was statistically significant(P < 0.001).According to the changes of clinical symptoms,urinary protein excretion level,renal function level,blood glucose and glycosylated hemoglobin level before and after treatment,the curative effect is divided into invalid,effective and effective.Among them,8 cases were ineffective,33 cases were effective,21 cases were effective,the total effective number was 54 cases,the total effective rate was 87.1%.2.Before and after treatment,the value of urea was significantly lower than that before treatment,and the difference was statistically significant(P < 0.05).There was no significant difference in serum creatinine(P > 0.05).The value of cystatin decreased significantly after treatment(P < 0.05),and the value of uric acid decreased significantly after treatment(P < 0.05).3.After treatment,the value of glycosylated hemoglobin was significantly lower than that before treatment(P < 0.05).After treatment,fasting blood glucose was significantly lower than that before treatment(P < 0.05).4.Among the 62 patients included in this study,the highest proportion of TCM syndrome is spleen kidney qi deficiency syndrome(45.2%),and the majority of the standard syndrome is damp heat syndrome(74.2%).With the development of the course of the disease,blood stasis gradually increased.5.After treatment,the TCM syndrome score was significantly lower than before treatment,the difference was statistically significant(< 0.05).Using the system of traditional Chinese medicine assistant inheritance platform,we found that: the frequency and property of traditional Chinese medicine were statistically analyzed: the top 12 drugs were Poria cocos,Cornus officinalis,astragalus,dangshen,yam,peony bark,Alisma,Salvia miltiorrhiza,radix rehmanniae,wolfberry,radix paeoniae rubra and Achyranthes bidentata.The frequency of cold and cold medicine,warm and hot medicine and ordinary medicine was 34.39%,32.27% and 33.34% respectively.The proportion of acid,bitter,sweet,pungent,astringent and salty was 8.80%,21.27%,47.20%,14.96%,6.93% and 0.84% respectively.Conclusion:The highest proportion of diabetic nephropathy in TCM is spleen kidney qi deficiency(45.2%).In standard syndrome,the majority is damp heat syndrome(74.2%).With the development of the course of the disease,blood stasis gradually increased.Professor Zhang Peiqing's high frequency drugs for the treatment of diabetic nephropathy are Poria cocos,Cornus officinalis,astragalus,Codonopsis pilosula,yam and peony peel in turn;the commonly used drug combinations are Cornus Poria cocos,Codonopsis Poria cocos,Astragalus Poria cocos and Codonopsis Astragalus.TCM syndrome differentiation and treatment of diabetic nephropathy can improve clinical symptoms,reduce urinary protein excretion,protect renal function,improve metabolic function,and delay the development of the disease.