Clinical Research On Treating Postoperative Side Effects Of Interventional Surgery For Primary Hepatic Carcinoma With Yigan Xiaoliu Prescription

Objective:To explore the clinical effect of Yigan Xiaoliu prescription on the toxic and side effects of hepatocellular carcinoma after interventional therapy,and to provide a new idea and basis for the clinical treatment of adverse reactions after interventional therapy of hepatocellular carcinoma.Methods:The 45 patients with primary liver cancer who developed toxic and side effects after TACE(syndrome differentiation of spleen deficiency and blood stasis syndrome)were randomly divided into two groups.The control group(22 cases):On the first day after the operation,according to the test indicators and clinical symptoms of the patients,the patients were given symptomatic support treatment with conventional western medicine(such as Tropisetron hydrochloride,Compound glycyrrhizin,etc.).Treatment group(23 cases):on the first day after the operation,the control group was treated with Yigan Xiaoliu prescription on the basis of conventional western medicine symptomatic treatment.The treatment cycle of the two groups was 2 weeks,and the changes of KPS score,TCM symptom score,blood routine,liver fiunction,coagulation function,hemorheology and immune function indexes of the two groups before and after treatment,as well as the duration of adverse reaction symptoms after TACE were recordod and compared.Results:1.By comparing the indicators of the control group and the treatment group before and after treatment,it was found that the KPS score,TCM syndrome score,blood routine,liver function,coagulation function,hemorheology and immune function of the patients in the two groups improved after treatment compared to those before treatment,and all P values were less than 0.05,indicating statistically significant difference.2.Through subgroup studies,the TCM symptom score and KPS score of the treatment group were better than that of the control group(P<0.05);The levels of blood routine(WBC,RBC,PLT)and liver function(AST,ALT)indexes in the treatment group were superior to those in the control group(P<0.05);In terms of immune function,the levels of CD3+,CD4+ and CD4+/CD8+were higher in the treatment group than in the control group,while the levels of CD8+ and NK lymphocytes were lower in the control group(P<0.05);In terms of coagulation function,PT,APTT and TT indexes in the treatment group were higher than those in the control group,while FIB indexes were lower than those in the control group(P<0.05);In terms of hemodynamics,the hemorheology(plasma viscosity,erythrocyte sedimentation rate,hematocrit,blood equation K)of the treatment group was lower than that of the control group(P<0.05);The duration of adverse reactions after TACE in the treatment group was significantly shorter than that in the control group(P<0.05).Conclusion:Yigan Xiaoliu prescription can effectively shorten the course of postoperative complications in patients with primary liver cancer after intervention,reduce bone marrow suppression and liver function damage,improve the degree of blood stasis and TCM symptoms of the body,improve the physical condition of patients,and enhance the immune function of patients.