Clinical Observation Of Fuzheng Xiaoliu Prescription Combined With TACE And Microwave Ablation For Primary Liver Cancer

Objective: To objectively evaluate the effectiveness and safety of Fuzheng Xiaoliu prescription combined with TACE and microwave ablation for primary liver cancer by clinical observation,and discuss the efficacy and advantages of its.Methods: 60 patients with primary liver cancer who met the criteria for inclusion in this study were randomly divided into treatment group and control group,with 30 cases in each group.On the basis of basic treatment,both groups were given TACE followed by microwave ablation.At the same time,the treatment group was treated with Fuzheng Xiaoliu prescription and addition or subtraction with the certificate.The course of treatment was 2months.After the end of treatment,observe and compare the effects of solid tumors,clinical symptoms of TCM,AFP levels,Child-Pugh score and grade of liver function,KPS score,and other indicators.Meanwhile,monitor safety indicators and adverse reactions,and perform statistical analysis.Results: Before treatment,there was no significant difference between the two groups in gender,age,presence or absence of hepatitis B,clinical symptoms scores of TCM,AFP levels,Child-Pugh score and grade of liver function,KPS score,etc.The difference was not statistically significant(P>0.05).Comparison of clinical curative effect after treatment:(1)Comparison of curative effects of solid tumors: After treatment,there was no complete response in the two groups.The treatment group achieved partial response in 19 cases,stable disease in 7 cases,progress disease in 4 cases,the objective response rate was63.3%,the disease control rate was 86.7%;the control group achieved partial response in 15 cases,stable disease in 9 cases,progress disease in 6 cases,the objective response rate was50.0%,the disease control rate was 80.0%.There was no statistical difference in the efficacy of solid tumor between the two groups(P>0.05).(2)Comparison of clinical symptom scores of TCM: After treatment,clinical symptom scores of TCM of both groups were improved compared with before treatment,and the improvement in the treatment group was significant compared with the control group.The differences were statistically significant(P<0.05).(3)Comparison of clinical curative effect of TCM: After treatment,in the treatment group,6 cases were markedly effective,22 cases were effective,2 cases were ineffective,the total effective rate was 93.3%;in the control group,2 cases were markedly effective,20 cases were effective,8 cases were ineffective,the total effective rate was 73.3%,the clinical efficacy of TCM in the treatment group was better than that in the control group.The difference was statistically significant(P<0.05).(4)Comparison of AFP levels: After treatment,the AFP levels in both groups decreased compared with those before treatment,and the decline in the treatment group was significant compared with the control group.The differences were statistically significant(P<0.05).(5)Comparison of Child-Pugh score and grade of liver function: After treatment,there was no significant difference in the Child-Pugh grade of liver function between the two groups compared with before treatment(P>0.05).However,comparing the Child-Pugh score of liver function,the treatment group decreased compared with that before treatment.The decrease was statistically significant(P<0.05).There was no significant difference between after treatment and before treatment in the control group(P>0.05).The difference between the two groups after treatment was statistically significant(P<0.05).(6)Comparison of KPS score: After treatment,the KPS scores of the two groups were improved compared with before treatment,and the treatment group was more significant than the control group.The difference was statistically significant(P<0.05).Comparison of KPS scores efficacy of the two groups: In the treatment group,20 cases were improved,9cases were stable,1 cases were decreased;In the control group,12 cases were improved,14 cases were stable,and 4 cases decreased.The curative effect of the treatment group was obviously better than that of the control group.The difference was statistically significant(P<0.05).Safety evaluation: There were no statistically significant differences in blood routine,urine routine,stool routine,liver and kidney function,blood coagulation function,electrocardiogram between the two groups before treatment(P>0.05),and they were comparable.After treatment,except for albumin,there was no significant difference in changes of the other indexes between the two groups before treatment(P>0.05).Albumin levels in both groups increased compared with before treatment,and the increase in treatment group was more obvious than that in control group.The difference was statistically significant(P<0.05).There were no obvious adverse reactions in the two groups during thetreatment,and there was no withdrawal of the researchers due to adverse reactions.Conclusion: Fuzheng Xiaoliu prescription combined with TACE and microwave ablation for primary liver cancer can significantly improve clinical symptoms,improve quality of life,reduce AFP levels,increase albumin levels,and can improve liver reserve function to a certain extent without obvious toxic side effects.Clinical application is safe and effective.