Clinical Observation Of Tiaochang Decoction In The Treatment Of Senile Functional Constipation With Deficiency Of Qi And Yin

Objective: the purpose of this study is to observe the clinical efficacy of Tiaochang decoction in the treatment of elderly functional constipation(deficiency of qi and Yin),and to evaluate the efficacy,recurrence rate,TCM symptom score,safety and other aspects,so as to provide a reference for the clinical treatment of elderly functional constipation.Methods: 1.64 elderly patients with functional constipation(deficiency of qi and Yin)were admitted to the expert clinic of spleen and stomach department of hubei provincial hospital of traditional Chinese medicine from September 2018 to September 2019.The patients were randomly divided into observation group and control group according to the order of treatment,with 32 cases in each group.The observation group was treated with tiaochang decoction,while the control group was treated with lactulose for 4 weeks.Observe and record the symptoms before treatment,after treatment,one month after drug withdrawal,and two months after drug withdrawal,and conduct statistical analysis to compare the differences in effective rate,TCM symptom score,recurrence rate,long-term efficacy and other aspects between the two groups.2.The collected data were analyzed by SPSS21.0 statistical software.Chi-square test was used for counting data,independent sample rank sum test was used for grading data,and t test was used for measurement data.Results:1.There was no significant difference between the two groups in terms of pac-qol score Wexner score,constipation score and other aspects(P>0.05).2.Efficacy evaluation: a total of 63 patients completed this study.In the observation group,32 patients were cured,21 showed significant effect,5 were effective,2 were ineffective,and the total effective rate was 93.80%.Control group in 31 cases,1 case healed,16 cases of pay off,9 cases effective,5 cases ineffective,the effective rate of observation group total effective rate 83.90% higher than that of control group,two groups of curative effect comparison(P = 0.029 < 0.05,the curative effect is similar between the two groups have statistical significance in the two groups after treatment in patients with symptoms of TCM PAC-total integral QOL score Wexner constipation score were lower before the treatment(P < 0.05)and after treatment,the observation group of patients above three marks are lower than the control group(P < 0.05)in observation group for TCM symptom score in abdominal distension dry mouth god fatigue lazy fall.The improvement of symptoms in the four categories of exclusion was better than that in the observation group3.Long-term efficacy: return visit in the first month after treatment: in the observation group,there were 30 cases,among which 2 cases relapsed,28 cases did not relapsed,and the recurrence rate was 6.67%.In the control group,there were 26 cases with recurrence,7 cases with recurrence,and 19 cases without recurrence,with recurrence rate of 26.92%.The relative ratio of recurrence in the two groups was P=0.040 < 0.05,the recurrence rate in the observation group was lower than that in the control group,and the difference was statistically significant.2 months after treatment,30 patients in the observation group were revisited,among which 3 had relapsed,27 had not relapsed,and the recurrence rate was 10.00%.In the control group,there were 26 cases with recurrence,9 cases with recurrence,17 cases without recurrence,and the recurrence rate was 34.62%.The relative ratio of recurrence in the two groups was P=0.025 < 0.05,the recurrence rate in the observation group was lower than that in the control group,and the difference was statistically significant.4.Safety evaluation: during the study period,no adverse reactions,toxic side effects and other adverse events occurred in both groups,and no significant abnormalities were found in blood,urine,fecal routine,liver and kidney function,or electrocardiogram before and after treatment.Conclusion:1.Tiaochang decoction and Lactulose can achieve good clinical efficacy in the treatment of functional constipation and deficiency of qi and Yin in the elderly.In contrast,tiaochang decoction is more effective.2.Tiaochang decoction and Lactulose can improve the quality of life of elderly patients with functional constipation,qi and Yin deficiency.Tiaochang decoction improved the quality of life of these patients more than lactulose.3.Both tiaochang decoction and Lactulose had recurrence after treatment,and tiaochang decoction had better long-term effect on elderly functional constipation.4.Tiaochang decoction has obvious clinical efficacy and good safety,which can be further studied and promoted clinically.