| Objective:The purpose of this clinical study was to observe the effects of acupuncture at Jiaji acupoint plus Dumai moxibustion on VAS pain score,morning stiffness,occipital wall distance,Schober test,ESR,CRP,and liver and kidney function(ALT,Cr)in patients with ankylosing spondylitis impact,to analyze the clinical efficacy of this therapy in patients with ankylosing spondylitis,so as to provide a safe and effective method for clinical treatment of this disease.Method:The subjects of this study were all from patients with ankylosing spondylitis who were treated in the Department of Acupuncture or Rheumatology of Hubei Provincial Hospital of Traditional Chinese Medicine between October 2018 and October 2019,and randomly divided them into acupuncture group and drug group,30 cases per group.There was no statistical difference between the two groups in terms of age,gender and course of disease.In the acupuncture group,the intervention measures of acupuncture at Jiaji points plus Governor pulse moxibustion were adopted.Acupuncture selected bilateral Jiaji points at the affected area,and the needle was inserted obliquely along the direction of the spine after routine disinfection.Pulse moxibustion is treated once every 15 days,each time for 1h.30 days is a course of treatment,a total of two courses of treatment.The intervention in the drug group was oral administration of sulfasalazine enteric-coated tablets,3 times a day,0.5 g each time.30 days is a course of treatment,a total of two courses of treatment.The main outcome indicators were VAS score,morning stiffness time,pillow wall distance,thoracic activity,Schober test,ESR,CRP;safety indicators were liver and kidney function(ALT,Cr).Result: 1.After two courses of treatment,the VAS scores of the acupuncture group and the drug group were statistically significant compared with those before treatment(P<0.05).The VAS scores of the acupuncture group and the drug group were compared between groups,and the difference was not statistically significant(P>0.05).2.The difference in morning stiffness score between the acupuncture group and the drug group after two courses of treatment was statistically significant compared with that before treatment(P <0.05).The difference between the acupuncture group and the drug group was statistically significant(P<0.05).3.After two courses of treatment,the difference between the occipital wall distance between the acupuncture group and the drug group was statistically significant compared with that before the treatment(P<0.05).Compared between the acupuncture group and the drug group,the difference was not statistically significant(P> 0.05).4.After two courses of treatment,the difference in thoracic activity between the acupuncture group and the drug group was statistically significant compared with before treatment(P<0.05).The thoracic activity between the acupuncture group and the drug group was not statistically significant(P>0.05).5.After two courses of treatment,the difference between the acupuncture group and drug group Schober test data compared with before treatment was statistically significant(P<0.05),the acupuncture group and drug group Schober test data were compared between groups,the difference was not statistically significant(P>0.05).6.After two courses of treatment,the ESR of the acupuncture group and the control group was statistically different than that before the treatment(P<0.05).The ESR of the acupuncture group and the drug group was compared between the groups after treatment,the difference was statistically significant(P<0.05).7.After two courses of treatment,the CRP of the acupuncture group and the drug group was statistically different than that before the treatment(P<0.05).The CRP of the acupuncture group and the drug group was statistically significant(P<0.05).8.After two courses of treatment,no patients in the acupuncture group had ALT higher than the reference value range,and 8 patients in the drug group had ALT higher than the reference value range.After chi-square test,the difference was statistically significant(P<0.05).9.After two courses of treatment,no patients in the acupuncture group had Cr higher than the reference value range,and 8 patients in the drug group had ALT higher than the reference value range.After chi-square test,the difference was statistically significant(P<0.05).Conclusion:This study found that after treatment with acupuncture at Jiaji acupoints plus Du pulse moxibustion or oral enteric-coated tablets of sulfasalazine,the VAS score,morning stiffness time,and occipital wall distance of patients with ankylosing spondylitis were reduced compared with before treatment,while the thoracic expansion degree and Schober trials increased compared with before treatment,and ESR and CRP decreased compared with before treatment,indicating that both interventions can improve the clinical symptoms of patients with ankylosing spondylitis and improve the quality of life.Comparison between groups after two courses of treatment showed that there was no significant difference in the effects of the two interventions on the VAS score,occipital wall distance,thoracic expansion,and Schober test,while the morning stiffness time,ESR,and CRP in the acupuncture and drug groups.The comparison between the groups showed that the intervention measures of the acupuncture group were better than the oral medicine group.That is,in relieving the clinical symptoms of patients with ankylosing spondylitis and improving the quality of life,acupuncture at Jiaji points plus Dumai moxibustion is superior to oral sulfasalazine enteric-coated tablets.Before and after treatment in the acupuncture group,ALT and Cr did not appear to be higher than the reference value range.After treatment in the drug group,there were 8 cases and 5 cases of ALT and Cr higher than the reference value range,respectively.The difference in science indicates that in terms of safety evaluation,acupuncture at Jiaji points plus Dumai pulse moxibustion is superior to oral sulfasalazine enteric-coated tablets,which has less effect on liver and kidney functions and fewer adverse reactions. |
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