| Objective:Under the guidance of the theory of "prevention of disease" in traditional Chinese medicine,taking the patients with common clinical spleen deficiency,damp heat and blood stasis type colorectal adenoma treated by endoscopy as the research object,the effect of Erteng Sanjie Capsule on recurrence and improvement of clinical symptoms after resection of colorectal adenoma was objectively evaluated by using the method of random control,so as to provide an effective Chinese medicine scheme for the prevention of recurrence of colorectal adenoma Bas is for supply.Methods:From December 2018 to December 2019,72 patients with colorectal adenomas who met the diagnostic criteria and included criteria in the Department of Oncology and Splenogastric Diseases of Shanxi Ho spital of traditional Chinese Medici ne were treated with complete resection of colorectal polyps in our hospital.the patients with postoperative adenomatous polyps were randomly divided into two groups: Erteng Sanjie treatment group(nasty 36)and control group(nasty 36).The control group received routine fluid replacement and nutritional support for 3 days without drug intervention,while the Erteng Sanjie treatment group received the same postoperative support treatment as the control group,and could be treated with Erteng Sanjie capsul e after eating.The specific medication was 2 tablets after three meals a day for 3 months.After taking the medicine,the TCM symptoms of the two groups were evaluated,and the results of enteroscopy were reexamined aft er 6 months of treatment.Statistical software was used to objectively evaluate the clinical effect of Erteng Sanjie capsule on recurrence of colorectal adenoma after endoscopic treatment.Results:(1)The recurrence rate of polyps was 14.28% in the treatment group and 25.71% in the control group,P = 0.232 > 0.05,indicating no significant difference.(2)In the comparison of sex,smoking history,age distribution,BMI and recurrence,P value was > 0.05,indicating that recurrence of adenoma had no significant relationship with sex,smoking history,age and BMI.In the comparison of adenoma pathology,adenoma number,adenoma location and recurrence,P value was greater than 0.05,which indicated that t here was no significant difference between adenoma recurrence and adenoma pathology,adenoma number and adenoma location.In the comparison of the size and recurrence of adenoma,the statistical test showed that P < 0.01,indicating that the recurrence of adenoma was significantly related to the size of adenoma.(3)The clinical effective rate of Erteng Sanjie treatment group and observation control group was 88.57% and 71.43%,respectively,and P value was 0.007(< 0.01)by rank sum test.According to the s tatistical results,the clinical effective rate of Erteng Sanjie treatment group was significantly different from that of the control group.(4)The standard deviation of adding and subtracting the total integral of TCM syndrome in the treatment group and t he control group was 3.71 ± 0.54 and 6.05 ± 0.61 respectively,which showed that the total integral of TCM syndrome in the treatment group was significantly improved compared with the control group(P < 0.05).(5)After treatment,the scores of abdominal distention,Nada,times of defecation and habit of defecation in Erteng Sanjie treatment group were compared with those in the control group(P < 0.05),which was statistically significant,indicating that the improvement of abdominal distention,Nada,times of defecation and Burning of anus in Erteng Sanjie treatment group was better than that in the control group.Compared with the control group,there was significant statistical difference between the two groups(P < 0.01).There was no statistical significance between the two groups in the comparison of abdominal pain score and stool character score by rank sum test(P > 0.05).(6)The liver and kidney function of the experimental group and the control group were not abnormal before and after treatment.In th e comparison of creatinine,urea,alanine aminotransferase and glutamic oxaloacetylase of the two groups before and after treatment,all P values were more than 0.05,indicating that there was no statistical difference in the comparison within the group.A fter the treatment of creatinine,urea,alanine aminotransferase and glutamic oxaloacetylase,it was found that all P values were more than 0.05,with no difference It has statistical significance.After treatment,the ECG of each patient was normal.Conclusion:(1)The recurrence of adenomatous polyps was affected by th e diameter of polyps.(2)The effective rate of clinical symptoms of patients after CRA can be significantly improved after taking Erteng Sanjie capsule.(3)After the treatment of Erteng Sanjie capsule,all clinical symptoms of CRA patients were improved,abdominal pain symptoms,asthenia degree,stool frequency,stool habits,stool characteristics were significantly improved,abdominal distention and appetite were also improved.After the operat ion,only observing the patients' asthenia and abdominal distention degree,the other symptoms were improved.(4)Compared with the control group,the two-vine dispersal control group can reduce the recurrence of patients with rectal adenoma polyps to a certain extent,but it is not statistically significant,the dosage form is convenient and safe and reliable. |
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