Clinical Observation Of Qifang Liujun Decoction And Mannan Peptide In The Treatment Of Repeated Respiratory Tract Infection In Children With Deficiency Of Lung And Spleen Qi

Objective:To compare the effects of Qifang Liujun Decoction combined with Mannan peptide oral solution on the incidence of disease,course,type of disease,TCM syndrome score,and humoral immunity in children with lung and spleen deficiency syndrome.Objectively evaluate the effectiveness and safety of Qifang Liujun Decoction in the treatment of this disease,To provide an objective basis for the treatment of children with RRTI by integrated traditional Chinese and western medicine.Methods:Sixty-six patients meeting the inclusion criteria were randomly divided into a treatment group and a control group,with 33 cases in each group.The treatment group was treated with Qifang Liujun Decoction combined with the Mannan peptide oral solution,and the control group was treated with the Mannan peptide oral solution.Each group was treated for 8 weeks and followed up continuously for 12 months.Results:A total of 63 patients were collected,32 in the treatment group and 31 in the control group.For the number of incidences,both groups can reduce the number of incidences before and after treatment?P<0.01?.The difference between the treatment group and the control group after treatment is statistically significant?P<0.01?;Group 77.42%,the difference was statistically significant?P<0.05?.For TCM symptom scores,the effective rate of TCM syndrome scores in the treatment group is 93.75%and that in the control group is 80.65%,the difference is statistically significant?P<0.05?;after comparison between the two groups before and after treatment,the child's complexion,body shape,Symptoms of hyperhidrosis,dry stools,and lack of breathiness?P<0.05?,the treatment group has differences in improving the appetite and thin stools of the children?P<0.05?,the control group is improving the appetite and thin stools of the children There was no significant difference?P>0.05?;after treatment,the treatment group could improve the children's sweating,dry stools,and lack of breath Symptom?P<0.05?,can significantly improve the symptoms of children's body shape,appetite,loose stools?P<0.01?;There was no significant difference between the two groups in improving the complexion of the children?P>0.05?.For the condition,the effective rate of the therapeutic effect of the treatment group was 93.75%,and the control group was 80.65%,the difference was statistically significant?P<0.01?;compared with before and after treatment in the treatment group,in terms of improving the number of illnesses,condition,and disease type?P<0.01?,Compared with before and after treatment in the control group,in terms of improving the number of onsets and conditions?P<0.05?,in terms of disease types?P>0.05?;compared with the two groups after treatment,The treatment group can improve the frequency and duration of the children's disease?P<0.05?,and can significantly improve the disease type?P<0.01?.For humoral immune indicators,both groups before and after treatment can significantly improve the serum immunoglobulin IgA and IgG in children?P<0.01?;after treatment,the treatment group can significantly improve the serum immunoglobulin IgA,IgG level?P<0.01?.With regard to cellular immune indicators,both groups before and after treatment can significantly increase the peripheral blood T lymphocyte subsets CD₃⁺,CD₄⁺,CD₄⁺/CD₈⁺?P<0.01?;after treatment,the treatment group can significantly improve the disease Children's T lymphocyte subsets CD₃⁺,CD₄⁺,CD₄⁺/CD₈⁺?P<0.01?.Conclusion:Qifang Liujun Decoction combined with mannan peptide oral solution in treating children with repeated respiratory infections of lung and spleen qi deficiency type can effectively reduce the number of respiratory infection episodes,shorten the course of the disease,improve the symptoms of appetite,body shape and stool in children The level of immunoglobulin and Tlymphocyte subsets in children has definite curative effect and is worthy of clinical promotion.