Clinical Observation Of Tiaozhi Granule In The Treatment Of Phlegm-Stasis-Associated Dyslipidemia

1 Research purpose To evaluate the efficacy and safety of tiaozhi granules in the treatment of patients with dyslipidemia with combined phlegm and blood stasis,so as to provide evidence-based medical evidence for the treatment of dyslipidemia with traditional Chinese medicine.2.Research methods This study will be included in the standard of 120 cases of phlegm and blood stasis by each type of dyslipidemia patients were divided into control group and in accordance with the principle of randomized controlled research group A and group B,group C,the control diet plus exercise therapy,the team are in the control group,on the basis of the team A given: capsules,team B lipid particles,group C give tiaozhi granule combined: capsules,regular treatment for 12 weeks,before and after treatment respectively records of TCM symptoms integral,Safety indicators such as TC,TG,LDL-C,HDL-C,Apo B,Apo A1,and liver and kidney function were observed,and the data obtained were analyzed by SPASS 26.0 statistical analysis software.3 Research results(1)comparison of the total curative effect of symptoms and the score of TCM symptoms: after treatment,the curative effect of the study group and the control group was significantly higher than that before treatment,and the difference was statistically significant(P<0.05).After treatment,the experimental group was superior to the control group,and the difference was statistically significant(P<0.05).Study group B was superior to study group A,and the difference was statistically significant(P<0.05).The comparative efficacy of study group C and study group B was similar,and the difference was not statistically significant(P>0.05).(2)comparison of TC,TG,LDL-C,HDL-C,Apo A1 and Apo B: after treatment,TC,TG,LDL-C and Apo B in the study group and the control group all decreased compared with before treatment,while HDL-C and Apo A1 levels increased,with statistically significant differences(P<0.05).After treatment,group C was significantly better than other groups,and group B was significantly better than the control group,with statistically significant differences(P<0.05).The efficacy of study group A and study group B was similar,and the difference was not statistically significant(P>0.05).(3)safety indicators: no patients with obvious blood routine and liver and kidney dysfunction were found in the study group and the control group after treatment,and the difference was not statistically significant(P>0.05).4 Conclusions 1.The combination of diet and exercise,xuezhikang capsule,tiaozhi granule,and xuezhikang capsule combined with tiaozhi granule can effectively improve the level of blood lipid index and the score of TCM syndromes in patients with dyslipidemia.2.The tiaozhi granule group,the xuezhikang group and the tiaozhi granule group were superior to the diet and exercise treatment group.The tiaozhi capsule group and the tiaozhi granule group had the best efficacy in improving the levels of total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,Apo B and Apo A1.3.Tiaozhi granules have a significant clinical effect,which is equivalent to the combination of xuezhikang and tiaozhi granules in terms of improving the total efficacy and TCM syndrome score;The improvement of total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,Apo B,and Apo A1 was comparable to that of xuezhikang.4.No obvious adverse reaction was found in the treatment of tiaozhi granules,which is safe and worthy of clinical promotion and application.This study provides valuable clinical experience for clinical practice.