| Objective(1)To evaluate the regulation effect of The Method of Activating Spleen-energy and Dissolving Turbidity(TMASDT)on blood lipid profile in patients with dyslipidemia.(2)To evaluate the effect of TMASDT on arteriosclerosis and blockage in patients with dyslipidemia.(3)To evaluate the efect of TMASDT on vascular endothelial function in patients with dyslipidemia.(4)To evaluate the effect of TMASDT on the quality of life of SF-36 in patients with dyslipidemia.(5)To evaluate the safety of TMASDT.MethodsA randomized,controlled clinical trial was used.A total of 94 outpatient and hospitalized patients admitted to guang 'anmen hospital from April 2015 to April 2018 were collected.By using the random number table method,the patients were randomly divided into Huazhuo Tiaozhi Granules Give Medicine(HZTXGGM)group and the control group,and the group was eventually included in the experimental group of 38 and Atorvastatin Calcium Tablets Control Medicine(ACTCM)group of 46.1n HZTXGGM group,Huazhuo Tiaozhi Granules(HZTXG)were given,and atorvastatin calcium tablets were given 20mg/day in ACTCM group.Weight,abdominal circumference,blood lipid level,liver and kidney function,blood routine and urine routine were examined before and after 8 weeks of treatment.The FMD,NMD,baPWV,ABI and quality of life were measured after 8 weeks of treatment.SPSS statistics22 was used for statistical analysis.Results(1)The effect on blood lipids? Of HZTXGGM group CHO after treatment(4.582±1.032mmol/L)was significantly lower than CHO before treatment(4.830±1.269mmol/L),and the comparison was statistically significant(P = 0.035).0f ACTCM group CHO after treatment(3.715(1.388)mmol/L)was significantly lower than CHO before treatment(4.745(2.246)mmol/L),and the comparison was statistically significant(P = 0.001).The two treatments were statistically significant(P = 0.002),and ACTCM group was superior to HZTXGGM group.?Of HZTXGGM group LDL-C after treatment(2.780(1.120)mmol/L)was significantly lower than LDL-C before treatment(2.000(3.000)mmol/L),and the comparison was statistically significant(P=0.046).0f ACTCM group LDL-C after treatment(2.330(0.755)mmol/L)was significantly lower than LDL-C before treatment(3.420(1.835)mmol/L),and the comparison was statistically significant(P = 0.000).The two treatments were statistically significant(P=0.018),and ACTCM group was superior to HZTXGGM group.?Of HZTXGGM group TG after treatment(1.950(1.833)mmol/L)was not statistically significant(P = 0.814)compared with TG before treatment(2.100(1.745)mmol/L).Of ACTCM group TG after treatment(1.440(0.938)mmol/L)was not statistically significant(P=0.229)compared with TG before treatment(1.695(1.375)mol/L).The two treatments were statistically significant(P = 0.007),and the atorvastatin calcium tablets and HZTXG both can not reduce the TG level.?Of HZTXGGM group HDL-C after treatment(1.075(0.303)mmol/L)was not statistically significant(P=0.296)compared with HDL-C before treatment 1.000(0.228)mmol/L).Of ACTCM group HDL-C after treatment(1.010(0.468)mmol/L)was not statistically significant(P = 0.977)compared with HDL-C before treatinent(0.990,0.977,mmol/L).The two treatments were statistically significant(P = 0.907),and the atorvastatin calcium tablets and HZTXG both can not induce an increase in HDL-C.(2)The effect on arteriosclerosis and blockage?Right baPWV of HZTXGGM group(1375.33±285.78m/s)was superior to ACTCM group(1556.83±315.65m/s)(P=0.044).? There was no statistically significant difference(P=0.209)between left baPWV of HZTXGGM group(1428.93±290.16m/s)and ACTCM group(1535.94±301.47m/s).?There was no statistically significant difference(P=0.597)between right ABI of HZTXGGM group(1.11,0.20)and ACTCM group(1.13,0.24).?There was no statistically significant difference(P = 0.443)between left ABI of HZTXGGM group(1.13,0.16)and ACTCM group(1.09,0.30).(3)The effect on vascular endothelial function?FMD of ACTCM group(0.15±0.07)was superior to HZTXGGM group(0.10±0.07)(P=0.021).?There was no statistically significant difference(P 0.194)between HZTXGGM group(0.17,0.11)and ACTCM group(0.12,0.10).(4)The effect on the quality of life of SF-36?On PF there was statistically significant difference(P= 0.012)between ACTCM group(22.97±6.17)and HZTXGGM group(26.12±5.22).?On SF there was statistically significant difference(P = 0.002)between ACTCM group(8.49±2.08)and HZTXGGM group(9.59±1.97).?On RE there was statistically significant difference(P=0.013)between ACTCM group(5.03±1.20)and HZTXGGM group(5.56±0.99).?On changes in health there was statistically significant difference(P = 0.000)between ACTCM group(3.54± 1.09)and HZTXGGM group(2.20±0.88).?On total score there was statistically significant difference(P = 0.000)between ACTCM group(79.85±48.45)and HZTXGGM group(16.89±14.18).(4)The effect on security metrics?blood routine test:There was no statistically significant difference between the two groups of RBC,WBC and N%(P>0.05).There was no statistically significant difference between the PLT and HGB of ACTCM group(P>0.05).Of HZTXGGM group PLT after treatment(246.00(112.00)×109/L)change higher than PLT before treatment(208.50(60.00)×109/L)(P<0.05).Of HZTXGGM group HGB after treatment(147.00(25.00)g/L)change higher than HGB before treatment(138.00(24.75)g/L)(P<0.05).?liver and kidney function test:Of HZTXGGM group all indexes of liver and renal function were in the normal range before ad after the treatment,and the differences were not statistically significant(P>0.05).0f ACTCM group the ALT,AST,ALP,and y-GT were higher than before,and the difference was statistically significant(P<0.05),but all were within the normal range.?Adverse events:no adverse events occurred in both groups.Conclusions(1)TMASDT can reduce CHO and LDL-C level.(2)There was no difference in the improvement of arterial occlusion beteen two groups.TMASDT is superior to atorvastatin in improving the elasticity of artery.(3)In improving the function of endothelial function,atorvastatin improved FDM superior to TMASDT.And there was no statistically significant difference between the two groups in NMD.(4)For the effect quality of life score of SF-36,TMASDT is superior to atorvastatin in physiological function,social function,emotional function and total score.Atorvastatin is better for improving patients' subjective assessment of health changes than TMASDT.(5)TMASDT is safe. |
PDF Full Text Request