Theoretical Summary Of Ancient Medical Literature For Alcohol-related Diseases And Experimental Research

Background:With the alcohol consumption increasing,the attack of alcoholism has been appeared to ascend.Excessive ingestion of alcohol, especially strong drink,can not only bring about damages to center neural system,digestive system,circular system,and so on,but also can endanger stabilization of family and society.Alcoholism has been a serious problem of sanitation and society.Alcoholism comprises acute alcoholism and chronic alcoholism.Regard to the treatment of acute alcoholism,there is short of real effective method in modern medicine, but a clear advantage does exist in Traditional Chinese Medicine (TCM).Objective:The study discusses Chinese medicine's effect of relieving alcohol toxicity by literature and animal experiments.The study expects to prove the curative effect of drug for anti-drinking on acute alcoholism and further for the alleviating a hangover protective mechanism on mucosal of acute alcoholism mice through the animal experiment and provide scientific and academic reference to prevent and cure acute alcoholism efficiently.Design:There are two stages in the study.At stage one,the theoretical model is studied on the basis of content analysis of literature research: at stage two,animal experiments.Stage one:literature studyResearch method and procedure:(1)Object for literature research:the TCM literature about ulcerative colitis is extensively collected, including the medical records by ancient TCM doctors.(2)Literature sampling:the collected literature is categorized,labeled and sampled. (3)The analytic unit is identified.(4)The tools for content analysis are framed.The scale for nuclear category about knowledge on disease differentiation,syndrome differentiation is set up and its consistency is evaluated.(5)Content analysis for TCM diagnosis and intervention, including qualitative and quantitive analysis.(6)Relevant explanation and comparison,establishment of the theoretical model.The main results:General condition:Totally 571 pieces of TCM literature are evolved in the study.And 429 pieces of prescriptions are evolved in the study which forms the prescription.To summery the knowledge of the name,pathogeny,pathogenesis, treatment,prescription of alcoholism in the literatures of ancient TCM, and correlative knowledge of modern medicine.The study emphasized concluding on the acute alcoholism treatment of TCM in recent several years,which will found a primary theory on discussing the function of Chinese medicine.Based on the study of literature,this subject is investigated through several aspects,viz.definition of alcohol-related diseases.Its manifestations and treatment,and recipes and drug for anti-drinking.The term "alcohol-related diseases"(Jiu Bing)was first recorded in Wang Shuhe's Canon of Pulsology,while abnormal drinking(Jiu Bei)was mentioned in Miraculous Pivot(Ling Shu).On Pathogenesis manifestsions of all diseases(Zhu Bing Yuan Hou Lun)gives the pathology and etiology great influence was exerted from Jin- yuan Dynasties concerning its treat.Stage two:animal experimentsMethods:150 male mice were randomized into groups,et al.I have alleviating a hangover and explore the effectiveness of drug for anti-drinking experiment respectively.Results:The acute alcoholism model was made.The number of drunkenness mice and the time of amethyst have significant difference in the drug for anti-drinking groups VS model group(P＜0.05)Conclusions:The drug for anti-drinking has the clear effectiveness of alleviating a hang—over,therefore,it has the definite protective action to acute alcoholic liver disease in the mice.I observed drug for anti-drinking curative effect on prevention of drunkenness through animal experiments.After duplicating the animal models of acute alcoholism,I studied influence of drug for anti-drinking on the lethargic time,spontaneous locomotion activity,the balance of act,and metabolism of alcohol of acute alcoholic mouse.I get the following results:Aqueous extract of drug for anti-drinking can resist the depression of alcohol on central neural system,which is shown by shortening the sleeping time,reducing amount of spontaneous locomotion activity caused by excitement of central neural system,improving the ataxia and improving study and memory of mice.It can decrease alcohol concentration in blood effectively.In summary,aqueous extract of drug for anti-drinking can mitigate the toxic signs and symptoms of acute alcohol,and has effect of relieving alcohol toxicity and preventing drunkenness through restraining the absorption of alcohol in the gastrointestinal tract and promoting the metabolism of alcohol in the liver.Conclusion:These literatures are investigated through several aspects,viz.definition of alcohol-related diseases,its manifestations and treatment,and recipes and drug for anti-drinking.The analytic methods such as content analysis and multiple analysis should be applied based on TCM knowledge so that fine and valid outcome can be expected. The animal experiments prove the curative effect of drug for anti-drinking on acute alcoholism and further for the alleviating a hangover protective mechanism on mucosal of acute alcoholism mice.