| Objective:To evaluate the efficacy and safety of Xinqi granules in the treatment of allergic rhinitis in children with pulmonary qi deficiency and cold syndrome by observing Xinqi granules and cetirizine hydrochloride oral solution and/or momisone furfuratenasal spray respectively.Methods: Children with allergic rhinitis who visited the pediatric outpatient department of Hubei hospital of traditional Chinese medicine from April 2019 to January 2020 were collected.Sixty children with allergic rhinitis who met the diagnostic criteria of traditional Chinese and western medicine were selected and randomly divided into the experimental group and the control group,30 cases each.The experimental group was given Xinqi granules orally,and the control group was given western medicine routine treatment.The treatment course was 4 weeks.The case observation form was recorded and filled in before treatment,2 weeks after treatment and 4 weeks after treatment.The changes of TCM syndrome score and nasal endoscopic signs score of the children were observed and recorded from the perspective of comparison before and after the group and between groups,and the safetyindexes were monitored.SPSS20.0 statistical software was used for data analysis and objective clinical efficacy evaluation.Results:(1)Comparison of total effective rate: after 2 weeks of treatment,4 cases(13.3%)of total effective rate,19 cases(63.3%)of effective rate and 7 cases(23.3%)of ineffective rate in the experimental group showed effective effect,with a total effective rate of 76.7%.In the control group,there were 6 cases(21.4%),14 cases(50%)and 8 cases(28.6%)that were effective,and the total effective rate was 71.4%.There was no significant difference between the two groups(P>0.05).Comparison of the total effective rate after 4 weeks of treatment: in the experimental group,18 cases(60%)were effective,9 cases(30%)were effective,and 3 cases(10%)were ineffective,with a total effective rate of 90%.In the control group,8 patients(28.6%)were effective,15 patients(53.6%)were effective,and 5 patients(17.8%)were ineffective.The total effective rate was 82.2%.The difference between the two groups was statistically significant(P<0.05),indicating that the total efficacy of the 4-week treatment group was better than that of the control group.(2)Comparison of total score of symptoms: the difference of total score of main symptoms between the two groups before and after treatment was statistically significant(P<0.05),indicating that both the experimental group and the control group had curative effects in improving the main symptoms,among which the experimental group was superior to the control group after 4weeks of treatment(P<0.05).The difference of the total score of secondary symptoms in the two groups before and after treatm ent was statistically significant(P<0.05),indicating that both the experimental group and the control group had an effect on the improvement of secondary symptoms,of which the experiment al group was superior to the control group for 2 weeks of treatment and 4 weeks of treatment(P<0.05).Comparison of signs before and after treatment and between groups: both groups showed improvement in turbinate enlargement before and after treatment(P<0.05).After 2 weeks of treatment,the experimental group was superior to the control group(P<0.05).After 4 weeks of treatment,there was no statistically significant difference betweenthe two groups(P>0.05).(3)Comparison of symptoms: before and after treatment of the main symptoms and between groups: before and after treatment,the differences in the main symptoms(nasal obstruction,runny nose,nasalitching,sneezing)between the two groups were sta tistically significant(P<0.05),indicating that the efficacy of the two groups was similar.After 2 weeks of treatment,the control group was superior to the experimental group in the improvement of nasal congestion,nasal itching and sneezing symptoms(P<0.05),and there was no difference between the groups in terms of runny nose clearing(P>0.05).After 4 weeks of treatment,the improvement of nasal congestion and runny nose in the experimental group was better than that in the control group(P<0.05).Comparison before and after treatment of secondary symptoms and between groups: before and after treatment,there was nost atistically significant difference in the control group in the improvement of wind fear and cold fear and self-sweating sympto ms(P>0.05),while the difference in the experimental group was statistically significant(P<0.05),indicating that the experi mental group had improved the symptoms of wind fear and cold fear and self-sweating.The symptoms of shortness of breath and lazy speech were not significantly improved in the two groups before and after treatment(P>0.05),and the difference of cough sputum density between the two groups before and after treatment was statistically significant(P<0.05),indicating that both groups could improve the symptoms of cough sputum density.Among them,after 2 weeks of treatment,the experimental group was su perior to the control group in the improvement of wind fear and cold fear and self-sweating symptoms(P<0.05),and there was no difference between the groups in the symptoms of cough phlegm and shortness of breath(P>0.05).After 4 weeks of treatment,the experimental group was superior to the control group in the improvement of wind fear,cold fear,sweating and cough phlegm(P<0.05),and there was no difference between the groups in the symptoms of shortness of breath and fatigue(P>0.05).(4)Comparison of observation period: after 2 weeks of treatment,the total efficacy of the experimental group and the control group was similar,while after 4 weeks of treatment,the total efficacy of the experimental group was better than that of the control group(P<0.05).Conclusion:Xinqi granules and western medicine routine group had curative effects on the improvement of children with allergic rhinitis's main symptoms,cough phlegm and nasal endoscopic signs,but the control group had no obvious therapeutic effect onwind and cold fear,and spontaneous sweating.Both groups had no therapeutic effect in improving shortness of breath and lazy speech.After 2 weeks of treatment,the total curative effect of the two groups was similar,and the total curative effect of the two groups was better than that of the control group after 4weeks of treatment.The results showed that Xinqi granules had obvious and safe efficacy in treating children with pulmonary qi deficiency and cold type allergic rhinitis,and more obvious efficacy in improving secondary syndrome.The longer the course of treatment,the more obvious the advantage,which may be related to the effect of traditional Chinese medicine on the whole. |
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