The Clinical Study Of Ganmai Jianpi Decoction In The Treatment Of Mild To Moderate Depression With Deficiency Of Heart And Spleen After Stroke

Objective:To investigate the clinical efficacy and safety of Ganmai Jianpi Decoction in the treatment of mild to moderate depression with deficiency of heart and spleen after stroke,and to compare it with western medicine in the treatment of post-stroke depression.Methods:94 subjects included in this study were randomly divided into treatment group(Ganmai Jianpi Decoction)and control group(delixin),47 in each group,with a course of 6 weeks.Treatment group:give Ganmai Jianpi Decoction,about 300ml water,take it once before breakfast,once after dinner,warm boiled water.The control group was given Flupentixol tablets twice a day for 6 weeks.In the course of the study,6 cases fell off,of which 2 cases in the treatment group stopped taking medicine by themselves and 1 case took other traditional Chinese medicine preparations for their own reasons.There were 3 cases in the control group who did not take drugs regularly,and the rest of the patients should have good natures.Therefore,86 cases were actually collected,including 44 in the experimental group and 44 in the control group.The curative effect was evaluated by Hamilton Depression Scale(HAMD),symptom score of traditional Chinese medicine and safety judgment of ALD.Results:1.Evaluation of curative effect:there was no significant difference between the two groups in HAMD and ADL before treatment(P>0.05),indicating that the two groups had comparability;after treatment,Ganmai Jianpi Decoction and delixin group could significantly reduce HAMD and ADL score(P<0.05)Both Ganmai Jianpi Decoction and delixin can improve the depression symptoms of stroke with deficiency of both heart and spleen;the difference between the two groups is statistically significant(P<0.05),the total effective rate of the treatment group is 93.2%,and the total effective rate of the control group is 81.8%,indicating that Ganmai Jianpi Decoction is better than delixin in improving the symptoms of TCM.2.Safety judgment:In the course of the study,6 cases fell off,of which 2 cases in the experimental group stopped taking medicine by themselves and 1 case took other traditional Chinese medicine preparations for their own reasons.In the control group,3 patients did not take drugs regularly,the rest patients should have good natures.The blood,urine,stool routine examination and biochemical indexes of the patient were in normal range,and the ECG was normal.Conclusion:Ganmai Jianpi Decoction and delixin are both safe and effective,and Ganmai Jianpi Decoction has a significant effect in improving depression and TCM symptoms of patients,which is worth further exploration.