A Clinical Study On The Treatment Of Spleen Deficiency And Dampness Of Diarrhea Irritable Bowel Syndrome With Anzhong Zhixie Decoction

Objective:In this study,the treatment group of Anzhong Zhixie Decoction and the control group of Aoti bromame tablet + Clostridium butyricum active bacteria capsule were used to treat diarrhea type irritable bowel syndrome with Spleen Asthenia and dampness excess syndrome,and the changes before and after symptom score were observed to evaluate the clinical effect and safety of Anzhong Zhixie decoction,so as to provide a new idea and reference for the clinical treatment of this disease in traditional Chinese medicine.Methods:From January 2019 to December 2019,94 IBS-D patients were randomly divided into two groups: the treatment group and the control group,47 cases each.During the treatment,the treatment group lost 2 cases,the control group lost 4 cases,and 88 cases were finally completed,including 45 cases in the treatment group and 43 cases in the control group There was no significant difference between the two groups in terms of gender,age,course of disease and symptom score before treatment.The treatment group was treated with " Anzhong Zhixie Decoction " as the treatment plan,Usage: 200 ml of water,one dose per day,morning and evening,one hour after meal,the control group was given the Aoti bromame tablet + Clostridium butyricum active bacteria capsule as the treatment plan,usage: Aoti bromame tablet,one tablet per time,twice a day,one hour after meal,Clostridium butyricum active bacteria capsule,three capsules per time,twice a day,one hour after meal,the course of treatment was four weeks;treatment After the observation and comparison of the two groups before and after symptom score changes to evaluate the clinical efficacy,and follow-up for 8 weeks,statistical comparison of the recurrence rate of the two groups,in order to evaluate the long-term efficacy of drugs.Results:1.Comparison before entering the group: the treatment group of Anzhong Zhixie Decoction and the control group of Aoti bromame tablet + Clostridium butyricum active bacteria capsule,the two groups in terms of gender,age,course of disease,symptom score,etc.through spss20.00 software statistical test,the results were p > 0.05,there was no significant difference,comparable.2.Overall efficacy comparison: after 4 weeks of clinical treatment,10 of 45 patients in the Anzhong Zhixie decoction treatment group were cured,18 effective,13 effective and 4 ineffective,with a total effective rate of 91.11%.Among 43 patients in the control group,6 were cured,8 effective,16 effective and 13 ineffective,with a total effective rate of 69.78%.After statistical test,the results were p < 0 01,the two groups have significant statistical significance,which shows that the overall clinical effect of the treatment group is significantly better than the control group.3.Comparison of total score of symptoms: before the treatment,the total score of symptoms in the treatment group of Anzhong Zhixie Decoction and the control group of Aoti ammonium bromide tablet + Clostridium caseinate live bacteria capsule were compared.After the statistical rank sum test,the results were p > 0.05,with no statistical significance and comparability.After the treatment,after the statistical rank sum test,the results were p < 0.01,with significant statistical significance The results of rank sum test before and after treatment showed that the difference was statistically significant(P < 0.01),suggesting that the two groups of drugs had significant effect on spleen deficiency and dampness type ibsd.4.Comparison of single symptoms after treatment: after treatment,all symptoms of the two groups were improved,among which,the treatment group was better than the control group in "stool times","abdominal distention and abdominal pain","Nadia"(P < 0.05),and the effect in "aggravating factors","mental fatigue and burnout" was significantly better than the control group(P < 0.01).5.Comparison of recurrence rate between the two groups: 8 weeks after the treatment,5 of 45 patients in the Anzhong Zhixie decoction treatment group had recurrence rate of 11.11%;13 of 43 patients in the control group had recurrence rate of 30.23%,and the results were p < 0.05 after the statistical card test,The difference was statistically significant,suggesting that the long-term effect of Anzhong Zhixie decoction was better than that of otinium bromide tablet + Clostridium butyricum live capsule.6.Safety index observation: during the clinical study period,no obvious abnormal results were found in blood,urine,stool,liver and kidney function and ECG in the treatment group of Anzhong Zhixie Decoction and the control group of Aoti ammonium bromide tablet + Clostridium butyricum live bacteria capsule before and after the treatment,indicating that the clinical application of anziaoxie decoction is safe and has no obvious toxic and side effects.Conclusion:The clinical efficacy of Anzhong Zhixie Decoction in the treatment of IBS-D with spleen deficiency and dampness is significantly better than that of Aoti ammonium bromide tablet + Clostridium caseinate live bacteria capsule,which can effectively alleviate the clinical symptoms of patients,and has safety,long-term effect is considerable,and is worthy of clinical application.