| Objective: The purpose of this study was to investigate the status of coal mine workers' mental health and MSDs,and explore the relationship between mental disorders,occupational stress and MSDs.Combined with the study of molecular biology,the effects of gene gene and gene environment interaction on mental disorders.Methods:(1)Stratified cluster sampling and a self-administered questionnaire survey were used.1800front-line coal miners with more than one year working experience from two large,medium and small coal mines(6 in total)were randomly selected as the research objects.The basic situation questionnaire,effort reward imbalance questionnaire(ERI),symptom checklist-90(SCL-90)and musculoskeletal disease questionnaire were conducted.(2)Polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP)was used to detect the BDNF and TPH2 gene polymorphisms in the mental disorder and non-mental disorder group(250 persons each),and analyze the relationship between genetic polymorphisms,environment and mental disorders.Results:(1)A total of 1675 valid questionnaires were collected and the effective rate was 93.06%.(2)633(37.8%)coal miners suffered from mental disorders;The detection rate of psychological disorders was higher in female,age 50~60,working age 15~42 years,two shifts,coal miners,unmarried,junior college and above,monthly income ? 5000 yuan(P < 0.001).(3)761(45.4%)coal miners suffered from occupational stress;the detection rate of occupational stress was the highest in the working age of 15~42 years,safety supervisors,and monthly income ?5000 yuan(P<0.05).(4)There were 948(56.6%)coal miners with musculoskeletal injuries in the past year.The top three annual prevalence rates were waist(39.3%),neck(31.6%),and shoulder(28.0%);The prevalence of MSDs was higher in female,age 50~60,working age 15~42,two shift group,coal miners,junior high schooland below,and income ? 5000(P<0.05).(5)The mental disorder of MSDs group was higher than that of non MSDs group(P<0.001);The prevalence of mental disorders in occupational stress group was higher than that in non-stress group.(6)The prevalence of MSDs in mental disorder group was higher than that in non mental disorder group;The prevalence of MSDs in occupational stress group was higher than that in non-stress group(P<0.01).(7)Multivariate logistic regression analysis showed that occupational stress and MSDs were the risk factors of mental disorders in coal miners.(8)Except for rs4131347 of TPH2 gene,the distribution frequency of rs6265 of BDNF gene,rs10835210 of BDNF gene,rs4570625 of TPH2 gene and allele were significantly different between the case group and the control group(P<0.05);The genotype of AA and AG at rs6265 of BDNF,AA and AC at rs10835210 of BDNF,GG at rs4570625 of TPH2 were susceptible to mental disorders.(9)BDNF gene A-A haplotype and TPH2 gene T-C haplotype increased the risk of mental disorders.BDNF gene G-A haplotype and TPH2 gene G-C haplotype reduced the risk of mental disorders.(10)Interaction existed between BDNF gene rs10835210,TPH2 gene rs4570625,and TPH2 gene rs4131347;MSDs interacted with BDNF gene rs6265 and TPH2 gene rs4570625(P<0.05).(11)The degree of MSDs,educational level,and TPH2 rs4570625 had a higher degree of impact on mental disorders.Conclusions:(1)MSDs,occupational stress and mental disorders are common among coal miners.(2)Occupational stress and MSDs can increase the risk of psychological disorders.(3)BDNF and TPH2 gene are associated with the occurrence of mental disorders.(4)There is a positive interaction between BDNF rs6265,TPH2 rs4570625 and MSDs on the occurrence of mental disorders in coal miners. |
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