Correlation Between VD,UA And The Incidence And Progression Of Parkinson's Disease

Objective:To analyze the differences in VD and UA levels between patients in PD group and healthy controls.To explore the correlation between VD and UA levels and the onset and progression of PD.Methods:1.Select 100 PD patients who were admitted to the First Affiliated Hospital of Xinjiang Medical University from January to November 2019and met the inclusion criteria.Collect age,gender,smoking history,hypertension history,diabetes history,etc.Data,and collect the results of laboratory tests such as VD,UA,blood calcium,LDL-L,FPG,GHb,Hcy,Cys C levels.2.Select 100 patients who were treated at the same time in the First Affiliated Hospital of Xinjiang Medical University to collect general patient information and the results of the above laboratory tests.3.Contrast and analyze the difference between the general condition of the PD group and the control group and the level of laboratory test results.4.A comparative analysis of the differences in the laboratory test results between the early PD group and the late PD group in the PD group.5.Analyze the correlation between the difference in VD and UA levels of patients in early PD group and patients in middle and late PD group with Hoehn-Yahr classification of PD patients.6.Multivariate analysis of the results with statistical significance in the single factor analysis.Introduce Logistic regression analysis model to analyze the impact of the above factors on the incidence of PD.Results:1.VD,UA,GHb,Hcy,Cys C levels in PD group were lower than those in control group(P<0.05).2.The VD and UA levels of patients in the middle and late PD group were lower than those in the early PD group(P<0.05).3.The levels of VD(r~2=0.589)and UA(r~2=0.547)in PD group were negatively correlated with Hoehn-Yahr classification.4.Multivariate analysis:High UA level is a protective factor for the onset of PD(OR=0.99,95%CI:0.983-0.996).Conclusions:High UA level is a protective factor for the onset of PD,and the risk of PD in high UA level is lower than that in low UA level.The levels of VD,UA,GHb and Hcy in PD group were lower than those in control group.VD and UA levels are negatively correlated with Hoehn-Yahr classification of PD patients,and can be used to assess the severity of disease in PD patients.