Clinical Study On The Relationship Between Serum Uric Acidlevel And Parkinson Disease

Objective: To investigate the characteristics of serum uric acid level in patients with Parkinson disease, and analyze serum uric acid levels among groups of PD patients with different gender, age, stage and UPDRS-Ⅲ scores. Methods:74cases of idiopathic Parkinson disease patients were selected as study cases from neurology department of the hospital during January1st,2012to December31st,2013. The cases included21female patients and53male patients, aged from44to88(69.19±1.174) years, and they were divided into two groups: middle-aged group (22patients, aged from44to64years), and elder group (52patients, aged from65to88years). Considering their H-Y stage,52cases patients were in early stage (H-Y1-2period),18patients in medium stage (H-Y2.5-3period) and4cases in advanced stage (H-Y4-5period). The extent of motor function damage were evaluated based on UPDRS-Ⅲ scores, and PD group was divided into three sub-groups, namely mild (≤30points,57cases), moderate (31-50points,9cases) and severe (>50points,8cases).74healthy controls were selected matching the gender and age distribution of the cases, with the average age of69.22±1.075. SPSS19.0software was used for statistical analysis and serum uric acid levels were shown as mean±standard deviation (x±S). P value less than0.05was considered to be the level of significance in statistical analyses.Results:1.Uric acid level in PD group was significantly lower than the level of serum uric acid level in the control group (P=0.004).2.In different gender groups, serum uric acid level in male PD group was significantly lower than the level in male control group (P=0.007). The level of uric acid in female PD was lower than the level of female control group, but the difference was not significant (P=0.308). 3.In different age groups, level of uric acid in elderly PD group was significantly lower than the level of elderly control group (P=0.035), and the level of uric acid in middle-aged PD was significantly lower than the level of middle-aged controls (P=0.028).4. The level of uric acid is negatively correlated with staging, but the trend was not statistically significant (P=0.752). The levels of uric acid in different stage groups were not significantly different (P=0.77, P=0.901) between male and female patients in PD group. The levels of uric acid in different stage groups were not significantly different (P=0.992, P=0.405) between elderly and middle-aged PD group.5. The levels of uric acid in different UPDRS-III score groups were not significantly different (P=0.465). The levels of uric acid in sub-groups with different UPDRS-III scores were not significantly different (P=0.451, P=0.792) between male and female patients in PD group. The levels of uric acid were not significantly different (P=0.166, P=0.350) between elderly and middle-aged PD groups with different UPDRS-III scores.Conclusions:1. Serum uric acid level in PD patients was significantly lower than the level in control group, and this difference was found in male patients, middle-age and elder patients, but not in female patients.2Serum uric acid levels were not significantly different among PD patients at different stages, and no relationship was found between staging and gender or age.3Serum uric acid levels were not significantly different among PD patients with different UPDRS-Ⅲ scores, and no relationship was found between UPDRS-Ⅲ scores and gender or age.