| Objectives:By analyzing and comparing the general and clinical data of patients with chronic obstructive pulmonary disease complicated with carotid atherosclerosis and those without chronic obstructive pulmonary disease in the geriatric department of the first affiliated hospital of kunming medical university,The purpose of our study was to analyze the correlation between chronic obstructive pulmonary disease and atherosclerosis,To explore whether the common carotid artery Intima media thickness(IMT)value can be used as an early indicator of atherosclerosis in patients with chronic obstructive pulmonary disease,and to analyze the correlation between carotid IMT value and clinical indicators.Methods:A retrospective analysis was performed on the hospitalized patients in the geriatric department of the first affiliated hospital of kunming medical university from January 1,2017 to December 31,2018.A total of 112 patients diagnosed with chronic obstructive pulmonary disease combined with carotid atherosclerosis by vascular ultrasound and pulmonary function examination were set as the case group.A total of 116 patients with carotid atherosclerosis without chronic obstructive pulmonary disease were selected as the control group.General information,blood routine,blood biochemical data,common carotid artery IMT value,forced expiratory volume in one second account for the percentage of predicted value,24-hour blood pressure and average heart rate were collected.The data of patients with chronic obstructive pulmonary disease complicated with carotid atherosclerosis and those without chronic obstructive pulmonary disease were compared and analyzed,and the data of patients with chronic obstructive pulmonary disease were compared in groups,and the correlation between the common carotid artery IMT value and clinical indicators was analyzed.Results:1.Among the selected subjects,case group included 112 patients with chronic obstructive pulmonary disease complicated with carotid atherosclerosis,whose age between 48 and 90 years old,with an average age of 74.09±9.22,including 86 males(76.80%)and 26 females(23.20%).The control group included 116 patients with carotid atherosclerosis without chronic obstructive pulmonary disease,whose age between 47 and 95 years old,with an average age of 72.62±9.17,85 males(73.30%)and 31 females(26.70%),there was no significant difference in age and gender between the two groups(p>0.05).2.The number of smokers in patients with chronic obstructive pulmonary disease was larger than that in patients without chronic obstructive pulmonary disease,and the difference between the two groups was statistically significant(p<0.01).3.Patients with chronic obstructive pulmonary disease complicated with coronary heart disease were more than those without chronic obstructive pulmonary disease,and the difference was statistically significant(p=0.04).4.There was no statistically significant difference between the two groups in the use of anti-hypertensive drugs,hypoglycemic drugs,lipid-regulating drugs and anti-platelet drugs(p>0.05);Only 11.60%of patients with COPD useed bronchodilators.5.The percentage of lymphocytes,total protein,albumin,fasting blood glucose,total cholesterol,triglycerides and low density lipoprotein cholesterol in the case group were lower than those in the control group,and the serum creatinine was higher than that in the control group,and the difference was statistically significant(p<0.05).6.The carotid artery IMT of patients with chronic obstructive pulmonary disease was greater than that of patients without chronic obstructive pulmonary disease,and the difference was statistically significant(p<0.01).However,the differences in IMT values between patients with different degrees of COPD were not statistically significant(p>0.05).7.The average heart rate of the case group was faster than that of the control group,and the difference was statistically significant(p<0.01).There was no significant difference in blood pressure between the two groups(p>0.05).8.There were no statistically significant differences in WBC,neutrophil percentage,lymphocyte percentage,hemoglobin concentration,platelet count,mean platelet volume,and fibrinogen in patients with different degrees of COPD(p>0.05).9.Pearson correlation analysis was used to analyze the relationship between IMT value and each index.IMT was positively correlated with age and creatinine(p<0.05),that is,IMT increased with age and creatinine.IMT is negatively correlated with albumin(p=0.02),that is,when albumin level decreases,IMT level will rise.The correlation between other indicators and IMT was not statistically significant(p>0.05).Furthermore,age,creatinine and albumin were taken as independent variables and IMT value as dependent variables.Linear regression analysis showed that age,creatinine and albumin were not correlated with IMT value(p>0.05).10.Pearson correlation analysis was performed between PLT and MPV in the case group,and it was found that there was a negative correlation between MPV and PLT(p<0.001),that is,the level of MPV decreased with the increase of PLT.Conclusions:1.Patients with COPD have a higher incidence of coronary heart disease than those without COPD.2.High smoking rate,low protein level,high blood creatinine level and rapid ventricular rate may be the cause of atherosclerosis in COPD.3.Carotid artery IMT can be used as an early indicator of atherosclerosis in patients with chronic obstructive pulmonary disease.4.Patients with COPD complicated with Other diseases should actively use bronchodilators to improve airflow limitation,as well as cardiovascular drugs. |
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