Study On Chronic Obstructive Pulmonary Disease With Peripheral Arterial Disease

Objective To discuss the relationship between Peripheral arterial disease(PAD)and Chronic obstructive pulmonary disease(COPD)by the level of pulmonary function and severity of the disease in Xining area.And provide recommendations for the early prevention and treatment of peripheral arterial complications in patients with COPD,finally improve their prognosis and living quality.Methods 80 patients with stable COPD after hospitalization in Xining area were selected as the experimental group,and 50 healthy patients were selected as the control group.All patients in the experimental group underwent lung function tests(FEV1pred,FEV1 / FVC)according to GOLD lung function The classification was divided into light,moderate,severe and extremely severe groups;the patient's CAT score,m MRC classification,and history of acute exacerbations were collected,and the results were divided into GOLD A,B,C,and D groups;all subjects were subjected to carotid ultrasound examination Carotid intima-media thickness(CIMT)and Doppler angiography were used to measure the ankle brachial index(ABI),and the CIMT and ABI values were compared between each group and the correlation analysis was performed.Results The abnormal rate of ABI in the experimental group was 57.5%(46/80),and the detection rate of peripheral arterial disease(PAD)was 13.8%(11/80),compared with the control group [(6.0%,3/50)(0.0%,0 / 50)] markedly increased;the rate of abnormal carotid arteries in the experimental group was 68.8.5%(55/80),and the detection rate of peripheral arterial disease(PAD)was 7.5%(6/80),compared with the control group [(16.0%,8/50)(0.0%,0/50)] significantly increased;the CIMT value of the experimental group(1.03 ± 0.21)was much higher than that of the control group(0.76 ± 0.19),and the ABI of the experimental group(0.96 ± 0.10)was much lower than The control group(1.13 ± 0.08)had statistically significant differences(P <0.05).The control group was compared with GOLD A,B,C,D groups and GOLD lung function group 1,2,3,and 4 groups,the ABI values showed a decreasing trend,the difference was statistically significant(P <0.05),while CIMT in GOLD There was no statistical difference between the lung function classification groups(P> 0.05),and there was an increasing trend among the GOLD classification groups,and the difference was statistically significant(P <0.05).The CAT score in the experimental group was linearly positively correlated with CIMT(r value equal to 0.44,P <0.05)and linearly negatively correlated with ABI value(r value was-0.56,P <0.05).In the COPD group,FEV1% pred and FEV1 / FVC% were linearly negatively correlated with CIMT values(r values were-0.08,-0.17,P> 0.05,no statistical difference),and linearly positively correlated with ABI values(r values 0.35,0.41,P <0.05).Conclusion The proportion of peripheral arterial disease in patients with COPD is significantly higher than that of healthy people of the same age.In patients with COPD,carotid artery abnormalities and ABI abnormalities occur early,and as the disease gradually worsens,arterial disease also gradually worsens;CAT scores,CIMT,and ABI There was a correlation between the values;pulmonary function results(FEV1% pred,FEV1 / FVC%)in patients with COPD were correlated with ABI values,but not with CIMT.ABI measurement and carotid color Doppler ultrasound examination at rest are of certain value for early screening and evaluation of PAD,and lower limb arterial color Doppler ultrasound has limited diagnostic value and early screening for PAD.