The Relationship Between Depression And The Levels Of Plasma Inflammatory Cytokines In Colorectal Cancer Patients

Objective: The incidence of depression in colorectal cancer(CRC)patients is very high and depression may have bad effects on the prognosis.Numerous studies have shown that the underlying biological mechanism of cancer-related depression(CRD)is closely related to the activation of inflammatory cytokines(CKs).Investigating the relationship between inflammatory CKs and depression in CRC patients may provide a reference for early serological diagnosis and targeted anti-inflammatory therapy.We selected a wider range of CKs and compared their levels in CRC patients with or without depression and explored the relationship between depressive symptoms and the inflammatory CKs.Methods: We enrolled 53 CRC patients(20 patients with depression and 33 patients without depression).The Hamilton Depression Scale 24(HAMD-24)was used to assess the severity of depressive symptoms of all subjects.LUMINEX was used to measure GCSF,GM-CSF,IFN-?,TNF-?,IL-2,IL-4,IL-5,IL-6,IL-8,MCP-1 and IL-10 levels in the plasma.Results: 1.The CRC patients with depression had significantly higher G-CSF,GM-CSF,IL-2,IL-4,IL-5,IL-6,IL-8,IL-10 than the patients without depression(P(27)0.05).There was no significant difference in the levels of IFN-?,TNF-?,MCP-1 and IL-10 between the two groups(P(29)0.05).2.Correlation analysis between the HAMD total score and CKs levels revealed positive correlations of depression with IL-6 and GM-CSF in all CRC patients(P<0.05);no statistically significant correlations between the HAMD total score and the remaining CKs were observed.(P>0.05).3.The multiple linear stepwise regression analysis showed that IL-6 is a positive predictor of the HAMD total score(standard ?=0.316,P=0.037);GM-CSF isn't a predictor of the HAMD total score(P>0.05).Conclusions: There exists a wider range of inflammatory CKs activation in CRC patients with depression and the severity of depression symptoms is positively associated with the levels of plasma inflammatory CKs in all CRC patients.