Analysis Of Risk Factors For Death In Hospitalized Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective:The clinical data of patients with acute exacerbation of chronic obstructive pulmonary disease?AECOPD?were collected and analyzed to explore the risk factors for death in hospitalized patients with AECOPD.The aim was to improve clinicians'awareness of the risk factors for death in patients with AECOPD,so as to take early interventions to delay the progression of the disease.Reduce disability and mortality and improve the quality of life of patients.Methods:This study is a retrospective study.The study subjects were AECOPD hospitalized patients from October 1st,2017 to October 1st,2018,Shaanxi Provincial People's Hospital,Department of Respiratory and Critical Care.Firstly,the cases that met the inclusion and exclusion criteria were screened,and the demographic characteristics,admission signs,laboratory results within 24 hours of admission,comorbidities and complications were collected.The clinical data were divided into survival group and death group.Statistical analysis was performed on the data of the two groups by SPSS21.0statistical software.The quantitative variables were in accordance with the normal distribution,the t-test was used for comparison between groups,the non-parametric test was used for non-parametric test?Mann-Whitney U test?,and the comparison between qualitative variables was performed by?²test.Statistical analysis was used for the above-mentioned single factor analysis.The index was used as an independent variable,and the clinical outcome was multivariate logistic regression analysis of the dependent variable,and the independent risk factors for death were obtained.Result:1.A total of 232 cases meeting the research requirements were collected,including 159 males and 73 females.The overall age ranged from 44 to 93 years,with an average age of 72.73±10.65 years,212?91.4%?survival,and 20?8.6%?deaths.The survival group was 144?67.9%?males,68 females?32.1%?,with an average age of72.32±10.55 years,15?75.0%?males and 5?25.0%?females with an average age of77.10±10.95 years.2.Age,smoking,aggravation times,WBC,neutrophil ratio,Hb,urea,cysC,FIB,cTnI,PCT,BNP,PaCO₂,sputum culture positive,ischemic heart disease,respiratoryfailure,pneumonia,heartrateFailure,cerebrovasculardisease,hypoalbuminemia,electrolyte imbalance,and chronic kidney disease were significantly different between the two groups?P<0.05?.3.Multivariate logistic regression analysis showed positive bacterial culture?OR 16.602,95%CI:2.978⁹2.562?,heart failure?OR8.228,95%CI:2.070³2.706?,cerebrovascular disease?OR 5.719,95%CI:1.572²0.805?,hypoalbuminemia?OR 4.739,95%CI:1.270¹7.686?,frequent exacerbation?OR 4.708,95%CI:1.878¹1.801?were independent risk factors for death in hospitalized patients with AECOPD.Conclusions:1.Age,smoking,number of aggravation,WBC,neutrophil ratio,Hb,urea,cysC,FIB,cTnI,PCT,BNP,PaCO₂,sputum culture positive,ischemic heart disease,respiratory failure,pneumonia,heart failure,Cerebrovascular disease,hypoalbuminemia,electrolyte imbalance,and chronic kidney disease are associated with death in hospitalized patients with AECOPD.2.Bacterial culture positive,heart failure,cerebrovascular disease,hypoalbuminemia,and frequent exacerbation are independent risk factors for death in hospitalized patients with AECOPD.