Clinical Significance Of Detecting Serum Complement C1q In Patients With Acute Coronary Syndrome

Objective: To investigate the diagnostic value of serum complement C1q in the differential diagnosis of ACS subtypes,and to explore the value of serum complement C1q in assessing the severity of coronary artery lesions in ACS patients.Methods: This study was mainly included in the diagnosis of ACS in the Department of Cardiology of our hospital from 2017-10 to 2018-10.The basic data were complete and the patients with coronary angiography were enrolled in 103 cases,including 23 cases of UAP,28 cases of STEMI and 52 cases of NSTEMI.The changes of serum complement C1q levels were compared between the three groups.According to the patient's Gensini score,the patients were divided into mild group(0 ? score < 32)30 cases,moderate group(32 ? score < 68)37 cases,which were severe group(Sixty-six patients with 68 ? scores were compared.Serve complement C1q levels were compared between the three groups.Spearman correlation analysis and multivariate logistic regression analysis were used to investigate the correlation between serum complement C1q and the severity of coronary lesions in ACS patients.The ROC curve was used to investigate the diagnostic value of serum complement C1q in patients with severe coronary artery disease.Results: There were no significant differences in age,gender,BMI,smoking history,history of diabetes,history of hypertension,dyslipidemia,UA,Cys-C between the ACS subgroups(P>0.05).The differences of cTnI,CRP,WBC,serum calcium and Gensini scores were statistically significant(P<0.05).There was no significant difference in complement C1q levels between the three groups(P > 0.05).According to the Gensini score,there were no significant differences in age,gender,BMI,smoking history,history of diabetes,history of hypertension,dyslipidemia,UA,Cys-C between the three groups(P>0.05).There were significant differences in the levels of systolic blood pressure,cTnI,CRP,and complement C1q between the three groups(P<0.05).Correlation analysis suggested that serum complement C1q waspositively correlated with CRP,cTnI,and Gensini scores(r=0.320,0.264,0.323;P=0.001,0.007,0.001);serum complement C1q was an independent risk factor for severe coronary lesions.ROC curve analysis indicated that serum complement C1q predicted AUC of 0.641 with severe coronary artery lesions and the best cut-off value was 179.1 mg/L.Conclusion: There is no significant difference in serum complement C1q between the ACS subgroups.The ACS subtype cannot be identified by serum complement C1q level.According to the Gensini score,the serum complement C1q levels among the patients in the light,medium and heavy groups are different.Statistical significance;serum complement C1q level was positively correlated with coronary artery lesions in ACS patients,and was an independent risk factor for severe coronary lesions;serum complement C1q predicts AUC of coronary artery lesions in patients with ACS is0.641,and the optimal cut-off value is 179.1 mg/L.