Relationship Between Glucose Metabolism And Bone Mineral Density Among Middleaged And Elderly Individuals

Objective To investigate the relationship between glucose metabolism and bone mineral density(BMD)in middle-aged and elderly people.Methods The baseline data of"REACTION study"in Lanzhou area were extracted,8504 residents aged 40 to 75 years in Lanzhou community were selected as subjects.Questionnaire surveys,physical examinations,laboratory examination,BMD and T value were collected and analyzed.According to the sugar metabolic state is divided into normal glucose tolerance(NGT),sugar regulation damaged(IGR)and diabetes mellitus(DM)group,and the and the covariance analysis to compare different sugar metabolic state,different DM calcaneal BMD differences between blood glucose control level.Pearson correlation analysis was used to explore the influencing factors of BMD.Logistic regression analysis was used to explore the correlation between IGR,DM and bone mineral content.Results(1)The mean BMD of the right calcaneus of the subjects was 0.535±0.132g/cm2,higher in men than in women(0.555±0.130vs0.526±0.132g/cm~2,P<0.05).The prevalence of IGR and DM was 27.8%and 23.6%,respectively.The prevalence of bone loss and osteoporosis was 31.3%and 3.8%,respectively.(2)The prevalence of bone mass reduction in NGT,IGR and DM groups were47.3%,29.8%and 22.9%,respectively,showing a gradually decreasing trend(all P<0.05).There was no significant difference in the prevalence of osteoporosis among the three groups(all P>0.05).(3)Covariance analysis showed that after adjusting for various confounding factors,calcaneal BMD of DM group was higher than that of NGT group and IGR group in the total population and female population(P<0.05),and there was no difference between the three groups of males.There was no difference in BMD among groups with different glycated hemoglobin levels(all P>0.05).(4)Pearson correlation analysis showed that calcaneal BMD was negatively correlated with age,SBP,TC,LDL-C,HDL-C(all P<0.05),and positively correlated with BMI,DBP,25(OH)D,smoking,drinking,and exercise(all P<0.05).Calcaneal BMD was positively correlated with FBG in males(r=0.044,P=0.028),female calcaneal BMD is negatively correlated with 2hPG(r=-0.038,P=0.003).(5)Logistic regression analysis showed that,compared with NGT group,DM was negatively correlated with reduced risk of bone mass after adjusting for various confounding factors(OR=0.791,P<0.05).DM was negatively correlated with the risk of osteoporosis in the general population and female population(OR value was 0.731and 0.665,respectively,P<0.05),but there was no correlation in the male population.IGR was not correlated with the risk of bone loss and osteoporosis.Conclusion Patients with DM have higher calcaneal BMD.DM was negatively correlated with reduced bone mineral content,while DM was negatively correlated with decreased bone mineral content in female population.There was no correlation between IGR and calcaneal BMD.There was no significant correlation between calcaneal BMD and blood glucose control in DM patients.