| Objective: In this study,we observed the changes of facial nerve function score(FNFS)and facial nerve function index(FNFI)in patients with peripheral facial paralysis treated by abdominal acupuncture.The levels of serum immunoglobulin IgA,IgG,IgM,serum cytokine interleukin-6(IL-6)and nerve growth factor(NGF)were measured before and after treatment.The above operations were to explore the clinical efficacy and mechanism and provide clinical basis abdominal acupuncture for the treatment of peripheral facial paralysis Methods: This study collected 40 cases which met the inclusion criteria and staging criteria,including 20 cases in acute phase and 20 cases in remission phase.After signing the informed consent,the patients in acute phase were randomly divided into treatment group and control group,10 cases in each group.The patients in remission phase were randomly divided into treatment group and control group,10 cases in each group.The patients in the treatment group were treated with abdominal acupuncture,while those in the control group were treated with routine acupuncture once a day,7 days as a course of treatment,with three consecutive courses of treatment.Before and after each course of treatment,the facial nerve function of each patient was evaluated,the changes of FNFS and FNFI were recorded,the changes of serum IgA,IgG,IgM,IL-6 and NGF were detected.Results: 1.The total effective rate of abdominal acupuncture group was 100% for peripheral facial paralysis patients.There was no significant difference between abdominal acupuncture group and routine acupuncture group(P>0.05).2.TThere was no significant difference in FNFS and FNFI between the two groups(P>0.05).3.The FNFS of the two groups after treatment was higher than that before treatment,with significant difference(P<0.001).FNFS in the acute and remission stages of the treatment group increased in turn in each course of treatment,with significant difference(P<0.05).In the control group,FNFS increased in turn after each course of treatment,with significant difference(P<0.05);in the remission stage,FNFS increased in turn,but there was no significant difference(P>0.05).4.The FNFI of the two groups after treatment was higher than that before treatment,with significant difference(P<0.001).The FNFI of acute stage patients in treatment group had significant difference only between the first and second courses of treatment(P<0.05);the FNFI of remission patients increased in turn in each course of treatment(P<0.05).In the control group,FNFI increased in turn in each course of treatment,with significant difference(P<0.05);in the remission stage,FNFI increased in turn from pre-treatment to the first and second courses of treatment,with significant difference(P<0.05).5.The IgG level in the treatment group was lower than that before treatment,with significant difference(P<0.05).In the acute stage,the IgG level in the treatment group was lower than that in the control group,but there was no significant difference(P>0.05).In the remission stage,the IgG level in the treatment group was lower than that in the control group,with significant difference(P<0.05).The levels of IgA and IgM in the two groups after treatment were lower than those before treatment,but there was no significant difference(P>0.05).6.TThe level of serum IL-6 in treatment group and control group after treatment was lower than that before treatment,with significant difference(P<0.01).The level of IL-6 in the treatment group was lower than that in the control group(P<0.05).The serum NGF level in treatment group and control group after treatment was higher than that before treatment,with significant difference(P<0.01).After treatment,the level of NGF in the treatment group was higher than that in the control group(P<0.05).Conclusion: 1.According to the criteria for determining the combined efficacy of FNFS and FNFI,the results showed that abdominal acupuncture therapy could improve both FNFS and FNFI in patients with PFP(P<0.001),and significantly improve the clinical symptoms of patients with PFP,indicating that abdominal acupuncture has significant clinical efficacy for PFP.2.According to different stages of peripheral facial paralysis,routine acupuncture therapy can improve FNFS and FNFI of patients in acute stage at the same time(P<0.05);abdominal acupuncture therapy can improve FNFS and FNFI of patients in remission stage at the same time(P<0.05).It shows that abdominal acupuncture therapy can improve the clinical symptoms of PFP patients in remission stage rapidly,while conventional acupuncture therapy can improve the clinical symptoms of PFP patients in acute stage rapidly.Therefore,it is suggested that conventional acupuncture should be used in clinical treatment of PFP patients in remission stage,and abdominal acupuncture therapy should be used in remission stage.3.Both abdominal acupuncture and conventional acupuncture can inhibit the expression of IL-6 and IgG in serum(P<0.01),promote the expression of NGF(P<0.01),inhibit autoimmune inflammation and improve facial nerve function.Compared with the conventional acupuncture group,the abdominal acupuncture group had better regulation on the above-mentioned neuroimmune factors in patients with PFP in remission stage(P<0.05).Therefore,abdominal acupuncture therapy may promote the recovery of facial nerve function by regulating the expression of neuroimmune factors. |
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