The Effect Of Deep Brain Stimulation Of Subthalamic Nucleus On Non-motor Symptoms In Parkinson's Disease

Objective To study the effect of deep brain stimulation(STN-DBS)on the non-motor symptoms(NMSs)in patients with Parkinson's disease.Methods All the patients,treated with bilateral STN-DBS,were collected general data,including age,gender,duration of disease,Hoehn-Yahr stage,to analyze their correlation with the disease.All the patients were assessed by Unified Parkinson's Rating Scale(UPDRS III)and Non-motor Symptoms Scale(NMSS)one week before and 12 months after surgery.The results were descriptively analyzed.Results 17 Patients at 12 months after STN-DBS had significantly improvedment in bradykinesia,tremor,rigidity and balance disorder(P<0.001),and the improvement rates were 75.56%,76.32%,82.98%,and 58.25%,respectively.The improvement rate of balance disorder was relatively low.The statistically significant differences in scores of non-motor symptoms were observed on sleep disorders and fatigue(P<0.001),mental and behavioral abnormalities(P<0.001),paresthesia(P=0.005),cognitive impairment(P<0.001),constipation(P=0.037),and postoperative improvement rates were 48.77%,47.21%,36.54%,40.00%,and 31.91%,respectively.There was a significant association of motor symptoms scores in PD patients with Hoehn-Yahr Stage(r=0.499,P=0.021).The NMSs scores were significantly associated with course of disease and Hoehn-Yahr Stage(P<0.05).The daily dosage of anti-Parkinson medication was significantly reduced by 46.62% 12 months after operation.Conclusion Bilateral STN-DBS is a safe and effective treatment for Parkinson's disease.It can significantly improve the motor symptoms and reduce the daily dosage of anti-Parkinson medication in Parkinson's patients,and can also improve some non-motor symptoms such as sleep disorders,fatigue,paresthesia,cognitive impairment and constipation.