| Objective: To investigate the effect of subthalamic nucleus stimulation(STN-DBS)on the non-motor symptoms in patients with Parkinson's disease and to analyze the factors that affect the improvement of symptoms in order to understand the relevant technical factors to improve the related treatment plan and technology.Methods:25 patients who underwent subthalamic nucleus stimulation in our hospital from September 2014 to December 2016 were followed up.The patients' medical history,imaging findings,operation plan,preoperative and the postoperative score were retrospectively analyzed.Results:There was improvement in 25 cases underwent STN-DBS on MDS-UPDRS-III scale after 1 week,among 21(84%)cases diagnosed as anxiety,STAI were improved yet without significance,20(80%)cases who claimed with fatigue took VAS-f and had a significant improvement,the improvement of VAS-P in 15(60%)cases with pain and related bothers was significant,those 22(88%)cases claimed they had orthostatic dizziness,but there was no improvement on orthostatic hypotension in all 25 cases.Conclusion: Precise positioning and implantation of subthalamic nucleus stimulation electrodes are essential for the improvement of motor and non-motor symptoms in patients with surgical indications.STN-DBS improves motor symptoms and some non-motor symptoms of Parkinson's disease.However,long-term follow-up is still required to assess its efficacy in different patients.The choice of postoperative programming parameters is of great importance to the long-term maintenance of efficacy. |
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