Preliminary Exploration Of The Correlation Of TCM Syndrome Differentiation After PCI In 151 Coronary Heart Disease Patients With Unstable Exertional Angina With Their Quality Of Life

Objective:This project had surveyed the quality of life in patients with different syndromes after percutaneous transluminal coronary intervention(PCI)for Unstable exertional angina(UA)using the Self Acceptance Questionnaire(SAQ)scale and SF-36 scale,so as to understand TCM syndrome type distribution of patients after PCI for UA.At the same time,preliminary study on the correlation between syndrome type and quality of life,so as to provide a new thinking for clinical prevention and treatment in traditional Chinese medicine(TCM).Methods:From February 2018 to February 2019,a total of 151 patients diagnosed wit h unstable exertional angina at 1 week after PCI in Department of Cardiology in Fuji an Provincial People's Hospital were selected in this study.The related data were coll ected from patients,and patient syndromes were differentiated into 3 groups by two p hysicians with deputy director title and above,namely,the sthenia of pathogenic factor group(including turbid phlegm and blood stasis syndrome,Qi stagnation and blood s tasis syndrome,and Qi stagnation due to cold congealing syndrome),the asthenia of h ealthy Qi and sthenia of pathogenic factor group(including Qi deficiency and blood st asis syndrome,Yang deficiency and blood stasis syndrome,Yang deficiency and turbid phlegm syndrome),and the asthenia of healthy Qi group(including Qi-Yin deficiency syndrome).The SAQ and SF-36 scales were adopted to survey the patients.In additi on,the Gensini integral,number of diseased coronary vessels,and quality of life char acteristics among different syndromes were compared,and the major factors affecting t he quality of life were summarized.Results: 1.The distribution of TCM syndromes in CHD unstable exertional angina patients at 1week after PCI from the most to the least is turbid phlegm and blood stasis syndrom e(23.8%),Qi deficiency and blood stasis syndrome(21.2%),Qi stagnation and blood stasi s syndrome(19.2%),Qi stagnation due to cold congealing syndrome(11.9%),Qi-Yin defi ciency syndrome(10.6%),Yang deficiency and turbid phlegm syndrome(6.6%),Yang defi ciency and blood stasis syndrome(6.6%).2.Differences in age,sex,smoking,alcohol consumption,medical history,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)among various groups were not statistically significnat(P>0.05).3.Gensini integral: sthenia of pathogenic factor group> asthenia of healthy Qi and sthenia of pathogenic factor group>Asthenia of healthy Qi group.Compared with sthenia of pathogenic factor group,differences in asthenia of healthy Qi and sthenia of pathogenic factor group,as well as in asthenia of healthy Qi group were statistically significant(P<0.05).In the sthenia of pathogenic factor group,differences of Qi stagnation due to cold congealing syndrome and Qi stagnation and blood stasis syndrome were statistically significant compared with turbid phlegm and blood stasis syndrome(P<0.05);in the asthenia of healthy Qi and sthenia of pathogenic factor group,Qi deficiency and blood stasis syndrome showed statistical significance compared with Yang deficiency and blood stasis syndrome(P<0.05).4.Number of diseased coronary vessels: the sthenia of pathogenic factor group and the asthenia of healthy Qi and sthenia of pathogenic factor group were dominated by the double-branch and three-branch lesion,while the asthenia of healthy Qi group was dominated by single-branch lesion.Differences in the sthenia of pathogenic factor group and the asthenia of healthy Qi and sthenia of pathogenic factor group were statistically significant compared with the asthenia of healthy Qi group(P<0.05).5.Total SF-36 scale score: differences in the four dimensions,including PF,RP,GH and VT,were statistically significant among all groups(P<0.05).6.Total SAQ scale score: differences in three dimensions,including physical limitation degree,angina attack and treatment satisfaction,were statistically significant among all groups(P<0.05).7.The major factors that affected the quality of life included age,sex,smoking,alcohol consumption,TC,LDL-C,Gensini integral,number of diseased coronary vessels,medical history and TCM syndrome differentiation.Conclusions: 1.The most commom TCM syndromes in CHD unstable exertional angina patients at 1 week after PCI is turbid phlegm and blood stasis syndrome.2.The severity of coronary artery lesion of Qi-Yin deficiency syndrome at 1 week after PCI for CHD unstable exertional angina patients are Lightest.3.The quality of life of Qi-Yin deficiency syndrome at 1 week after PCI for CHD unstable exertional angina patients are poor.4.The major factors that affect the quality of life of CHD unstable exertional angina patients at 1 week after PCT include age,sex,smoking,alcohol consumption,TC,LDL-C,Gensini integral,number of diseased coronary vessels,and medical history,and TCM syndrome differentiation.