| ObjectiveTo observe the clinical efficacy of Bushen Huoxue granule in treating patients wit h knee osteoarthritis of kidney deficiency and blood stasis type,and its effects on cyto kines IL-1β,NO and TGF-β1 in knee joint fluid.Method105 patients with knee osteoarthritis of kidney deficiency and blood stasis type w ho complied with inclusion criteria of this subject research were divided into three gro ups:the western medicine group,the traditional Chinese medicine group and the combin ation of Chinese tradiational and Western medicine group by using random number ta ble method.There were 35 cases for each group.The western medicine group was trea ted with celecoxib capsule;The Chinese medicine group was treated with Bushen Huox ue granule;the combination of Chinese tradiational and western medicine group was tre ated with celecoxib capsule and Bushen Huoxue granule.The treatment observation peri od was 6 weeks and 3 weeks was a course of treatment.VAS score,WOMAC score an d syndrome score of patients were observed before and after treatment,and the level o f IL-1β,NO and TGF-β1 in synovial fluid were measured.Result1.There was no significant difference in sex,age,course of disease,pain VAS score and WOMAC score and other index among the three groups before treatment(P>0.05),data was comparable.2.VAS score:After 6 weeks of treatment,the three groups were compared within the group.The VAS score of the three groups was lower than that before treatment,a nd the difference was statistically significant(P<0.05).After treatment,compared within the group,the VAS pain score of the combination of Chinese tradiational and western medicine group was better than that of the western medicine group and the traditional Chinese medicine group,the difference was statistically significant(P<0.05);there was n o significant difference in VAS pain score within the western medicine group and the traditional Chinese medicine group(P>0.05).3.WOMAC score of knee joint: There was no significant difference in WOMAC score among the three groups before treatment.After 6 weeks of treatment,compariso ns within the group and between the groups were made.Compared within the group,t he WOMAC score of knee joint of the three groups was significantly improved after treatment compared with that before treatment(P<0.05).Compared between the groups after treatment,the WOMAC score in improving knee joint of combination of the Chi nese tradiational and Western medicine group was better than that of the western medi cine group and the traditional Chinese medicine group(P<0.05),and there was no signi ficant difference in WOMAC score between the western medicine group and the tradit ional Chinese medicine group(P>0.05).4.Syndrome score:There was no significant difference in syndrome score among t he three groups before treatment(P>0.05).After treatment,comparisons within the groupand between the groups were made.Compared within the group,the syndrome score of the three groups was significantly improved after treatment compared with that bef ore treatment(P<0.05).Compared between the groups,the syndrome score of combinati on of Chinese tradiational and Western medicine group was better than that of the we stern medicine group and the traditional Chinese medicine group after treatment,the d ifference was statistically significant(P<0.05),and there was no significant difference in the syndrome score between the traditional Chinese medicine group and the western medicine group(P>0.05).5.Cytokines IL-1β and NO: After 6 weeks of treatment,the patients’ level of cyt okines IL-1β and NO in the three groups were compared within the group and betwee n groups.After treatment,the patients’ level of cytokines IL-1β and NO were lower tha n the level of cytokines in knee joint fluid of the three groups before treatment,the di fference was statistically significant(P<0.05).Compared between the groups after treatme nt,the reducing the level of cytokines IL-1β and NO of combination of Chinese tradiat ional and Western medicine group was better than that of western medicine group and traditional Chinese medicine group(P<0.05),and there was no significant difference of IL-1β and NO between the western medicine group and the traditional Chinese medic ine group(P>0.05).6.TGF-β1: The level of TGF-β1 in knee joint fluid of the three groups was com pared between and within groups after treatment.Compared within the group,the leve l of TGF-β1 in knee joint fluid of patients in the three groups after treatment was hi gher than that before treatment,the difference was statistically significant(P<0.05).Co mpared between the groups,the improvement of the level of TGF-β1 in knee joint flu id of KOA patients of combination of Chinese tradiational and western medicine grou p was better than that of traditional Chinese medicine group and western medicine gro up after treatment(P<0.05).There was no significant difference in the level of TGF-β1 between the traditional Chinese medicine group and the western medicine group(P>0.05).7.After 6 weeks of treatment,the three groups all had effect(the traditional Chin ese medicine group was 78.13%,the western medicine group was 82.35%,and the co mbination of Chinese tradiational and western medicine group was 90.63%).The overall effective rate of the combination of Chinese tradiational and Western medicine group was the best,the difference was statistically significant.ConclusionTo treat patients with keen osteoarthritis of kidney deficiency and blood stasis typ e by using Bushen Huoxue granule can effectively relieve pain and improve knee fun ction of patients with knee osteoarthritis of kidney deficiency and blood stasis type.T he granule can also reduce the level of cytokines IL-1β and NO in synovial fluid,an d increase the level of protective factor TGF-β1.It has better therapeutic effect in co mbination with Western medicine,and is worthy of clinical promotion and application. |
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