| Objectives To observe the clinical effect of Jie Jei Xiao San Gao in the treatment of nontoxic nodular goiter(qi depression phlegm obstruction type),and to evaluate the clinical effect of Jie Jei Xiao San Gao.Methods From June 2017 to September 2018,60 patients who met the criteria were selected.All the subjects were from the outpatient and inpatient departments of Endocrinology Department of Shijiazhuang Traditional Chinese Medicine Hospital.After signing the informed consent voluntarily and informing the participants of the relevant matters,the subjects were randomly divided into two groups.The control group was given Euphorbia tablets orally,once a day at 25 UG each time.On the basis of the control group,the treatment group was given Nodule Dispersion Ointment,oral,1 bag,three times a day,12 weeks as a course of treatment.The information of TCM syndromes,related indicators of Western medicine and adverse reactions during treatment were recorded before and after treatment.SPSS 25.0 software was used to analyze the difference between the two groups.Results In 60 cases of this study on the toxicity of nodular goiter(qi depression phlegm obstruction type)patients in clinical trials for 12 weeks,the result is as follows: 1 Comparison of Western medical effect: After treatment,1 case was cured in the control group,7 cases were markedly effective,8 cases were effective,14 cases were ineffective,the total effective rate was 53.33%.In the treatment group,4 cases were cured,10 cases were markedly effective,10 cases were effective and 6 cases were ineffective,the total effective rate was 80.00%.The difference between the two groups was statistically significant(P < 0.05).2.Comparison of TCM syndromes: After treatment,the control group cured 0 cases,markedly effective 0 cases,effective 7 cases,ineffective 23 cases,the total effective rate was 23.33%;the treatment group cured 0 cases,markedly effective 3 cases,effective 22 cases,ineffective 5 cases,the total effective rate was 83.33%.The difference was statistically significant(P < 0.05).3 Comparison of total scores of TCM symptoms: After treatment,the total scores of the control group decreased from 31.43±3.94 to 28.10±7.31 and the total scores of the treatment group decreased from 31.00±3.82 to 17.57±5.65.There was a significant difference between the two groups(P<0.05);there was a significant difference between the treatment group and the treatment group(P<0.05).It shows that the treatment group is superior to the control group in improving the total score of TCM syndromes.4.Comparisons of single symptom scores of TCM: From the point of view of main symptom scores,after treatment,in the control group,except cervical distension and pharyngeal blockage,the other main symptom scores decreased compared with those before treatment(P < 0.05).After treatment,the scores of all main symptoms in the treatment group were lower than those before treatment(P < 0.05).And after treatment,the treatment group compared with the control group,the difference was statistically significant(P < 0.05).There was no significant difference in the scores of secondary symptoms between the two groups before and after treatment(P > 0.05).In the treatment group,the scores of each syndrome before and after treatment were significantly different except for epigastric fullness(P < 0.05).After treatment,the scores of the two groups were compared,and the difference was statistically significant(P < 0.05).5 Comparison of the diameter of the largest thyroid nodule: After treatment,the diameter of the largest thyroid nodule was significantly reduced in both groups,and the diameter of the nodule in the treatment group(5.44 ± 2.00)was significantly better than that in the control group(8.48 ± 2.52),the difference between the two groups was statistically significant(P < 0.05).It shows that the treatment group has more advantages in improving the diameter of the largest thyroid nodule.6 Comparing the number of thyroid nodules: After treatment,the number of thyroid nodules in the treatment group was significantly different from that before treatment(P < 0.05).7 Comparison of thyroid function and antibody: Before treatment,there was no significant difference in thyroid function and antibody between the two groups(P > 0.05).After treatment,there was no significant difference in thyroid function and antibody between the two groups(P > 0.05).8 Comparisons of liver and kidney functions: Before and after treatment,the liver and kidney functions of the two groups were within the normal range,and there was no significant difference(P > 0.05).Conclusions Analysis of the data of this observation study shows that the combination of Jie Jei Xiao San Gao and Levothyroxin Sodium Tablets has a better effect in the treatment of non-toxic nodular goiter(qi depression phlegm obstruction type)than that of Levothyroxin Sodium Tablets alone.There were no abnormal thyroid function,thyroid-associated antibodies and liver and kidney functions.Therefore,the treatment of non-toxic nodular goiter(qi depression phlegm obstruction type)with Nodule Dispersion Ointment is worthy of promotion and further study.Figure0,Table13,Reference 111... |
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