Role Of Porphyromonas Gingival In The Development Of Esophageal Squamous Cell Carcinoma

Objective:To investigate whether Pg plays a key role in promoting the development of precancerous esophageal lesions into cancer.Methods:Seventy-three patiens with precancerous lesions diagnosed by pathology between February 2007 and December 2012 were included retrospectively,which were divided into the experimental group(33cases)and the control group(40cases).The experimental group included patients with precancerous lesions 5years ago and diagnosed with cancer 5 years later.The control group was diagnosed with precancerous lesions 5years ago,and the patients were still diagnosed with precancerous lesions 5 years later.Take two groups of immunohistochemical samples,using immunohistochemical method to detect the two groups of five years ago and after five years group of township samples Pg protein expression,the expressionof each group Pg situation(immunohistochemical score)to carry on the t test,analysis of whether statistically difference,discusses Pg in the process of precancerous lesions develop cancer whether has played a key role in promoting.Results:1.40 patiens in the control group,16 patients with positive Pg infection 5 years ago,positive rate of infection was 40.0%,and the negative rate was 60.0%;18 patients with positive Pg infection 5 years later,positive rate of infection was 45.0%,and the negative rate was 55.0%;the positive rate of Pg infection increased by 5% after 5 years.Pg immunohistochemistry score between the two groups was tested by t test,with a P=0.0318,and the difference was statistically significant.2.33 patients in the experimental group,14 patients with positive Pg infection 5years ago,positive rate of infection was 42.4%,and the negative rate was 57.6%;18patients with positive Pg infection 5 years later,positive rate of infection was54.5%,and the negative rate was 45.5%;the positive rate of Pg infection increased by12.1% after 5 years.Pg immunohistochemistry score between the two groups was tested by t test,with a P=0.0341,and the difference was statistically significant.3.The Pg expression between the two groups was statistically analyzed,and the results showed that the positive rate of Pg in the experimental group was 42.4% fiveyears ago,significantly higher than the control group's 40.0%,the Pg immunohistochemistry score between the two groups was tested by t test,with a P=0.0230,and the difference was statistically significant;After 5 years,the Pg positive rate in the experimental group was 54.5%,significantly higher than the control group's 45%,the Pg immunohisto-chemistry score between the two groups was tested by t test,with a P=0.0321,and the difference was statistically significant;After 5 years,Pg infection increased by 12.1% in the experimengtal group,which was significantly higher than5% in the control group.The added value of Pg immunohistochemistry score between the two groups was tested by t test,P=0.0167,and the difference was statistically significant.Conclusions:Among the loyal patients with precancerous lesions of esophagus,the Pg infection rate of the patients who eventually developed cancer was significangly higher than that of the patients who did not develop cancer.The Pg infection rate also increased significantly.It suggests that Pg may play a key role in promoting the denelopment of precancerous lesions into cancer.