Study On The Correlation Of Pentraxin 3 And Hypersensitive C-reactive Proteinlevel With The Degree Of Nervous Functional In Patients With Acute Cerebral Infarction

Objective:To explore the correlation of pentraxin 3(PTX3)and high sensitivity c-reactive protein(hs-CRP)with the degree of nervous functional and prognosis in patients with acute cerebral infarction,provide theoretical basis for the disease progress and outcome.Methods:The experimental group consist of 150 patients with acute infarction who were admitted into the neurology department of our hospital during September2017 to March 2018 and the onset time was less than 24 hours,and 103healthy people who underwent physical examination in our hospital during the same period were collected as the control group.Record the information of two groups,including age,gender,history of hypertension,history of diabetes,smoking history,drinking history,platelet count,uric acid(UA),creatinine(Cr),homocysteine(Hcy),low density lipoprotein cholesterol(IDL-C),high-density lipoprotein cholesterol(HDL-C),total cholesterol(TC),triglycerides(TG),examine experimental index of PTX3 and hs-CRP.Patients in the case group were evaluated by the National Institute of Health stroke scale(NIHSS)score.The patients were divided into mild cerebral infarction group(NIHSS score<5)and severe cerebral infarction group(NIHSS score>5).Neurological function was scored according to the modified Rankin scale(mRS)score,and the patients were divided into the group with good prognosis(mRS score>2)and the group with poor prognosis(mRS score>2).The Spearman correlation analysis was used to analyze the correlation between each indicator and the NIHSS score,the mRS score as well.Use the Univariate and Multivariate logistic regression analysis to explore the risk factors affecting the severity and prognosis of cerebral infarction.Results:1.Compared with the case group,the levels of PTX3,hs-CRP,TC,IDL-C,Hcy and UA in the control group were lower than those in the case group(P<0.05).There were no statistically significant differences between the two groups in age,gender composition ratio,history of hypertension,history of diabetes,history of smoking,history of drinking,platelet count,TG,HDL-C,and Cr parameters(P>0.05).2.Set cerebral infarction severity as dependent variable,respectively by PTX3,hs-CRP,TG,TC,LDL-C,HDL-C,Hcy,UA,Cr,platelet count,age,gender composition ratio,smoking history,drinking history,history of diabetes,history of hypertension as the independent variable of single factor of orderly Logistic stepwise regression analysis,and then set statistically significant independent variables(including PTX3,hs-CRP,LDL-C,Hcy,UA)as the independent variable of orderly multiariable Logistic regression analysis,Results PTX3(OR=1.221,95%CI 1.088-1.370,P<0.05),hs-CRP(OR=1.162,95%CI 1.084-1.247,P<0.05)and homocysteine(OR=1.052,95%CI 1.017-1.088,P<0.05)were independent risk factors for the severity of ACI.3.According to Spearman correlation analysis,PTX3 and hs-CRP levels were positively correlated with NIHSS score(r_s=0.391,0.435)and mRS score(r_s=0.399,0.405)in patients with acute cerebral infarction(P<0.05).4.The levels of PTX3,hs-CRP,LDL-C,Hcy and TC in the group with good prognosis were all lower than those in the group with poor prognosis(P<0.05).There were no significant differences between the two groups in HDL-C,TG,UA,Cr,gender composition ratio,smoking history,drinking history,age,history of hypertension,history of diabetes,and platelet count(P>0.05).5.Receiver operating characteristic curve(ROC)curve showed that the area under the curve of PTX3 and hs-CRP with poor prognosis was 0.730 and0.703(P<0.05),the diagnostic boundary value was 18.170ng/ml and6.160mg/L,the sensitivity was 54.3%and 50.0%,and the specificity was83.7%and 84.6%,respectively.The condition of the prognosis of patients with acute cerebral infarction whether good or poor was used as the dependent variable,and TC,IDL-C,Hcy,PTX3 levels>18.170ng/ml and hs-CRP>6.160mg/L were used as independent variables for orderly multivariate Logistic regression analysis.It was shown that PTX3levels>18.170ng/ml,hs-CRP>6.160mg/L,IDL-C and Hcy were independently correlated with poor prognosis.It can be seen that PTX3>18.170ng/ml(OR=5.707,95%CI:2.181~14.930,P=<0.05)and hs-CRP>6.160mg/L(OR=8.692,95%CI:3.062~24.667,P=<0.05)can be used as independent risk factors for poor prognosis of acute cerebral infarction.Conclusions:The serum PTX3 and hs-CRP were positively correlated with the severity of acute cerebral infarction at admission,and were the independent risk factors affecting the severity of cerebral infarction.The serum PTX3 and hs-CRP were positively correlated with the prognosis of acute cerebral infarction at admission,and had positive predictive value for the prognosis of acute cerebral infarction.High levels of serum PTX3 and hs-CRP were independent risk factors for poor prognosis of patients with acute cerebral infarction.