| Objective: To observe the effects of Fasudil Hydrochloride Injection to the dynamic changes in serum levels of high-sensitivity C-reactive protein(Hs-CRP),vascular endothelial growth factors(VEGF),Interleukin 6(IL-6)and neural function in patients with acute cerebral infarction.Meanwhile,discusse the possible mechanism of Fasudil in anti-inflammation in acute cerebral infarction patients.We attempt to find out the relationship between serum IL-6 concentration nd infarct volume.We also study on serum concentration of Hs-CRP and IL-6 association with the degree of neurological deficits and functional outcome.Method: Collect 84 cases of the patients who sufferring the acute cerebral infarction and receive inpatient treatment on March to November 2016 in the Second Hospital of Hebei Medical University,Department of Neurology.Among them,which 56 cases were male and 28 females,the age range 30 to 80 years old.The participates were divided into two groups randomly:fasudil group(n = 45)and control group(n = 39).All two the treatment course were 10 days.There were no significant differences in age,gender and complications between the two groups.Taken the participate's blood samples on the second and tenth day separately.Meanwhile,record the basically data and evaluated the score of NIHSS on admission and on the tenth day.All patients underwent CT/MRI Scan,the infarct volume was determined according to the Pullicino formula.They were divided into three groups by five suoke subtypes based on TOAST criteria.Separating serum for ELISA detection of the levels of serum VEGF?IL-6,while Hs-CRP was performed by Biochemical and Immunological Department.All the data collected were analyzed by SPSS statistic software.Measurement data were expressed as mean±standard deviation.If data distribution meet the coincidence with the normality and variance,complete randomized two-sample t-test should come to the first.If not,multiple independent samples non-parametric tests,independent sample Wilcoxon rank sum test would be a better choice.Count data compared with in group should use R×C chi-square test.Define the significance level ?=0.05,with P<0.05 was considered statistically significant.Spearman rank correlation was optional for the nonparametric test correlation analysis,define the significance level ?=0.01,with P<0.01 was considered both of them were in correlated.Results:1 The age and gender between the control group(n=39)and fasudil group(n=45),has no significant difference in statistics.Similarly,the levels of triglycerides,low density lipo-protein,cholesterol;major complications such as history of hypertension,acute coronary disease,diabetes,history of cerebral infarction;the bad behavior referred to drinking and smoking are consistent with the result above(P>0.05).However,the levels of high homocysteine,(P<0.05)goes against that;2 The control group,the fasudil group,which the levels of the serum Hs-CRP in the two groups were no significance statistically before treatment(P=0.927,P>0.05);after treatment,which the levels of serum Hs-CRP were declined,but the two groups there were no significance statistically(P =0.920,P>0.05);3 The control group,the fasudil group,which the levels of the serum VEGF in the two groups were significance statistically before treatment(P =0.007,P<0.05);after treatment,which the levels of serum VEGF were increased,and the two groups there were significance statistically(P =0.003,P<0.05);4 The control group,the fasudil group,which the levels of the serum IL-6 in the two groups were no significance statistically before treatment(P=0.114,P>0.05);after treatment,which the levels of serum IL-6 were declined,and the two groups there were significance statistically(P=0.043,P<0.05);5 The excellence rate has statistical significance(P=0.000,P<0.05),while The utility rate between the two groups has no significance statistically(P =0.235,P>0.05);6 There was no correlation between serum Hs-CRP and NIHSS score before and after treatment(P>0.01).There was no correlation between serum Hs-CRP and ADL score before and after treatment(P>0.01).There was no correlation between serum IL-6 and NIHSS score before treatment(P>0.01).There was a correlation between serum IL-6 and ADL scores after treatment(P<0.01);7 With the increase of infarct volume,serum IL-6 concentration was increased,and there was significant difference between large,medium and small volume(P =0.025,P<0.05);Conclusions:1 Compared with the control group,the Fasudil group had superior anti-inflammatory ability and higher clinical treatment efficiency.2 Interleukin-6 may be appropriate for the indicator as inflammatory serological marker and associated with infarct volume,It can also assess the prognosis.Fasudil hydrochloride can significantly reduce its concentration,that is to say fasudil hydrochloride has a stronger anti-inflammatory ability and neuroprotective effect.3 Hs-CRP may not be used as a serological marker of acute cerebral infarction,and has no significant correlation in severity evaluation and prognosis. |
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