Correlation Between NLR,hs-CRP And Acute Cerebral Infarction

OBJECTIVE : This study analyzed the relationship between NLR and hs-CRP and acute cerebral infarction,and compared their application value in acute cerebral infarction.This study analyzed the correlation between NLR,hs-CRP and acute cerebral infarction,and compared their application value in acute cerebral infarction.It is to further explore the clinical significance of NLR in acute cerebral infarction,and provide a reference for early assessment of the severity and prognosis of acute cerebral infarction.METHODS:A prospective,single-center study included 160 patients with acute cerebral infarction and 131 patients who were hospitalized for "dizziness and discomfort".Blood routine examination and detection of hs-CRP and other related indicators after admission,and baseline clinical data such as age and gender were collected,and NLR values were calculated.The grouping is based on the severity of the disease,the size of the infarct size,the etiology and prognosis of patients with acute cerebral infarction.Statistical analysis was used to analyze the relationship between NLR,hs-CRP and acute cerebral infarction and its severity,infarct size,cerebral infarction classification and poor prognosis.The receiver operating characteristic(ROC)curve was used to analyze the effects of NLR and hs-CRP on the diagnosis and prognosis of acute cerebralinfarction.RESULTS:1.The number of male patients,hypertension,smoking history,drinking history,homocysteine,uric acid,fibrinogen,hs-CRP and NLR in the ACI group were higher than those in the control group(p<0.05).Hypertension,smoking,fibrinogen,hs-CRP and NLR were independently associated with cerebral infarction(p<0.05).2.The area under the NLR ROC curve was 0.888,and the area under the hs-CRP curve was 0.693.The comparison of NLR values for the diagnosis of acute cerebral infarction was higher than that of hs-CRP.3.The differences of NLR and hs-CRP in the mild,moderate and severe cerebral infarction group were statistically significant(P<0.01).NLR was positively correlated with NIHSS score(R=0.555,P<0.01),while hs-CRP was weakly correlated with NIHSS score(R=0.234,P<0.01).4.NLR and hs-CRP were significantly different between the large infarction group,the middle area infarction group and the small area infarction group(P<0.05).NLR was moderately correlated with the diameter of the infarcted lesion(R=0.430,P<0.01),and hs-CRP was weakly correlated with the diameter of the infarcted lesion(R=0.235,P<0.01).5.The differences of NLR and hs-CRP among the subtypes were statistically significant(F=3.318,P<0.05).The NLR and hs-CRP of SAO group were lower than those of LAA group and CE group.The difference was statistically significant.(P values were all <0.05),and the hs-CRP of the SAO group was lower than that of the SOE group(P<0.05).6.The NLR and hs-CRP in the poor prognosis group were higher than those in the prognosis group(P<0.05).The ROC curve analysis showed that the area under the NLR curve was 0.664(95% CI: 0.557-0.771),and the area underthe hs-CRP curve was 0.620(95% CI: 0.508-0.731),the predictive value of both for the prognosis of cerebral infarction is similar.CONCLUSION: Men,hypertension,smoking,alcohol,homocysteine,uric acid,fibrinogen,hs-CRP,NLR are associated with acute cerebral infarction.Hypertension,smoking,fibrinogen,hs-CRP and NLR values were independently associated with acute cerebral infarction.NLR and hs-CRP have certain reference value for the diagnosis and prognosis of acute cerebral infarction.NLR and hs-CRP were positively correlated with severity of acute cerebral infarction and infarct size,and they differ in the TOAST typing groups.