Changes Of Blood Routine Parameters In SSNHL Patients And Assessment Of The Effect Of Sound Therapy

Objective:(1)We explored possible relationships between sudden sensorineural hearing loss(SSNHL)in patients differing in terms of audiographic data and the levels of routine blood data.(2)To investigate the effect of sound therapy combined with traditional drug therapy(SDT)on gap detection threshold and speech recognition score in patients with sudden sensorineural hearing loss(SSNHL)Methods:(1)We included 37 patients with low-frequency SSNHL(LF-SSNHL),28 with high-frequency SSNHL(HF-SSNHL),32 with all-frequency SSNHL(AF-SSNHL),32 with total-deafness SSNHL(TD-SSNHL),and 31 age-and sex-matched healthy controls.Peripheral venous blood samples were collected,and routine blood parameters including white blood cell(WBC),platelet,neutrophil and lymphocyte count,neutrophil and lymphocyte percent,mean platelet volume(MPV),neutrophil-to-lymphocyte(NLR),and platelet-to-lymphocyte ratio(PLR)were measured.Each group was divided into recovery subgroup and unrecovery subgroup in accordance with hearing level after 1 month therapy,then compared the difference of WBC,neutrophil,platelet and lymphocyte count,MPV,NLR and PLR between the two subgroups.(2)SSNHL patients were grouped randomly into SDT group and drug therapy(DT)group.All the SSNHL patients received standard drug treatment and SDT group patients received sound stimulation for the affected ears for 7 days in addition We compared the pure tone audiogram(PTA),speech recognition scores at normal rate and time compressed(70%,60%,50%)in quiet and noise,gap detection threshold of SDT and DT group before treatment,at 7th and 30th day after treatmentResults:Neutrophil count,neutrophil percent and PLR of all SSNHL patients,WBC count and NLR of HF-SSNHL,AF-SSNHL and TD-SSNHL,MPV of AF-SSNHL and TD-SSNHL were significantly higher than those of control group(all P<0.05),while lymphocyte count and lymphocyte percent of HF-SSNHL,AF-SSNHL and TD-SSNHL patients was significantly lower than that of control group(all P<0.05).No significant difference was observed between platelet count of all SSNHL patients and control group(all P>0.05).However,the difference of platelet count,lymphocyte count,MPV,and PLR among audiographically distinct SSNHL patients was not significant(all P>0.05).In HF-SSNHL patients,lymphocyte count of unrecovery subgroup was significantly lower,while MPV and PLR of the unrecovery subgroup were significantly higher than those of recovery subgroup(all P<0.05).In AF-SSNHL patients,MPV of the unrecovery group was significantly higher than that of recovery subgroup(P<0.05).(2)There was no significant difference between the two groups in baseline levels.At 7th day after treatment,pure tone hearing was improved in both groups,but SDT group show significantly lower at 125 and 250 Hz than DT group(P<0.05).At 30th day after treatment,pure tone hearing differences between the two groups were not statistically significant(p>0.05).Both at 7th and 30th day after treatment,the speech recognition rate both at normal rate and time compressed in noise was significantly better in SDT group than in DT group(p<0.05)Conclusions:WBC,neutrophil count,neutrophil percent,lymphocyte count,lymphocyte percent,MPV,NLR,and PLR may be related to SSNHL,but they could not be used to distinct SSNHL audiographically.Lower lymphocyte,higher MPV,NLR and PLR may be indicative for the prognosis of HF-SSNHL patients;higher MPV may be related to bad treatment outcome of AF-SSNHL patients.(2)SDT may be beneficial to improve the pure tone hearing level,gap detection thresholds and speech recognition scores in noise for SSNHL patients.