The Application Of Procalcitonin And Procalcitonin Clearance In Prognostic Evaluation Of Sepsis

Objective: This study observed the relationship between procalcitonin(PCT)and procalcitonin clearance(PCTc)and sepsis in ICU patients,and explored the application value of PCT and PCTc in the prognosis of sepsis.Methods: Patients with sepsis who met the inclusion requirements in the emergency ICU of our hospital from January 2017 to December 2018 were retrospectively analyzed,and their basic information,clinical data,PCT concentration in admission for 24 h and PCT concentration on the morning of admission for the 3rd,5th and 7th days were collected,and PCTc on each day was calculated.Calculate APACHE ? score according to the worst indicator in admission for 24 h.On the basis of 28 days divided the patients into improvement group and deterioration group.Contrast between the two groups of PCT and PCTc differences,and assess the value of each index for prognosis.Results: There was no significant difference in PCT between the two groups on the 1st,3rd and 5th day.On the7 th day,the PCT of the deterioration group was higher than that of the improvement group.On the 3rd?5th?7th day the PCTc of the improvement group was higher than deterioration group.In assessing prognosis,PCTc-3 is similar to the APACHE ?.PCTc 5 and PCTc-7 is superior to the APACHE ?.Conclusion: The absolute value of procalcitonin can not be directly used to evaluate the prognosis.The procalcitonin clearance can evaluate the prognosis to some extent.In comparison,PCTc-7 has a better prognostic effect.