Clinical Significance Of The Serum Procalcitonin In Assessing The Severity And Prognosis Of The Patients With Sepsis

Objective：To evaluate the significance of serum procalcitonin （PCT）for est-imation of severity and prognosis in patients with sepsis.Methods：A total of46patients with sepsis were divided into three groupsaccording to clinical severity:early sepsis group,sever sepsis group and septicshock group.To study the difference of serum PCT,CRP,WBC and APACHEⅡscores in all groups and explore the prognostic significance of the biologicalmarkers,and correlation was analyzed between PCT and APACHEⅡ scores.Mea-nwhile,all patients were divided into three groups depending on different levelsof serum PCT:<5ng/ml group,5.0≤PCT≤10.0ng/ml group,≥10.0g/ml group.Themortality,the time of using antibiotics and hospital stay were analyzed.At the same time,the samples were performed the blood culture.Results：1． the levels of PCT,CRP,WBC and APACHEⅡscores in septic shockwere significantly higher than the severe sepsis group and the early sepsisgroup,compared the difference was significant(P<0.05).2． The levels of PCT, CRP and APACHEⅡ scores were significantlydifferent between early sepsis group and severe sepsis group(P<0.05),however,The level of WBC was not(P>0.05),and significant positive correlation betweenPCT and APACHE Ⅱ(r=0.68,P<0.05)was found.3． With increasing PCT levels,the morbidity, the length of using antibiotics and hospital stay increased(P<0.05),and the positive rate of the blood culture also improved.Conionclus： Detecting serum PCT could be useful for assessment of severityand prognosis in patients with sepsis.