Study On The Correlation Of Anticardiolipin Antibodies In Early Abortion And Late Abortion

Objective: Abortion is a common complication of obstetrics and gynaecology in the clinical work,which is defined as the termination of a pregnancy before the embryo or fetus is viable.Different countries and regions have different definitions of gestational weeks of abortion.In China,termination of a pregnancy before 28 weeks and with a fetus weighing less than 1,000 grams is called abortion.Those who occur before 12 weeks of gestation are called early miscarriages.If it occurs at 12 weeks gestation or later,it is called a late abortion.The etiology of abortion includes embryo factors,maternal factors,paternal factors and environmental factors.Maternal factors can be divided into the following categories: systemic diseases,genital abnormalities,endocrine abnormalities,severe stress,bad habits and abnormal immune function.At present,more and more attention has been paid to the causes of abortion caused by abnormal immune function.Antiphospholipid antibodies are a series of autoantibodies that target negatively charged phospholipids.Anticardiolipin antibody,(ACA)is one of the three antiphospholipid antibodies that are most recognized and most closely related to clinic work.The other two are lupus solid inhibitors and anti-?2 glycoprotein I antibodies.In recent years,domestic and foreign studies have shown that from the perspective of immune factors,the production of ACA is closely related to abortion.Anticardiolipin antibodies are associated with adverse pregnancy outcomes such as infertility,miscarriage,stillbirth,preeclampsia,and placental dysfunction.But in abortion,the relationship between ACA and gestational age,the relationship between ACA positive intensity and abortion rate,and whether intervention can reduce the incidence of adverse pregnancy outcomes in patients with ACA antibody abnormalities have been rarely reported.In view of this,this subject takes ACA as the research object,and conducts a preliminary study on the relationship between ACA blood content and abortion in a large number of pregnant women,aiming to further understand the influence of ACA on abortion,and to improve the poor prognosis of such patients in advance.The mitigation of pregnancy is assessed to reduce the psychological and financial burden on patients and their families by intervening in the adverse effects of ACA.Methods:1.The patients selected from the obstetrics and gynaecology clinic of the First Central Hospital of Baoding City were 560 cases of women with first pregnancy,no adverse pregnancy history,previous physical health and no bad habits.2.The concentration of anticardiolipin antibody(ACA)was determined by Enzyme linked immunosorbent assay(ELISA)and divided into positive and negative pregnant women.3.All were divided into an experimental group and a control group based on ACA positive(12RU/ml)and negative(< 12RU/ml)results.The patients were divided into early abortion(< 12 weeks)and late abortion(12-28 weeks),and were followed up to 28 weeks without any intervention.4.Thirty pregnant women who tested positive for ACA were selected and given intervention treatment for the adverse effects of ACA,to preliminarily explore whether the intervention of ACA can improve adverse pregnancy outcomes.5.SPSS software was used for statistical analysis,and chi-square test was used for counting data.P <0.05 was considered statistically significant.Statistical analysis can be used to understand whether ACA is related to the gestational age of abortion;to further understand whether the concentration of ACA is related to the occurrence of miscarriage,and to assess whether clinical measures to interfere with the adverse effects of ACA can improve adverse pregnancy outcomes.Results:1.The detection rate of ACA-positive pregnant women was 8%(45/560).The highest serum concentration of ACA was 60.09RU/ml and the lowest was 12.45 RU/ml.2.Among early miscarriages,the rate was 37.8 percent for ACA positive women and 22.7 percent for ACA negative women.The abortion rate of ACA-positive pregnant women was significantly higher than that of ACA-negative pregnant women,P=0.023,which was statistically significant.3.In late abortion,the abortion rate of ACA-positive pregnant women was 14.3%,and the abortion rate of ACA-negative pregnant women was 5%.The abortion rate of ACA-positive pregnant women was significantly higher than that of ACA-negative pregnant women,P=0.040,which was statistically significant.4.Among ACA-positive pregnant women,the early abortion rate was 37.8% and the late abortion rate was 14.3%,suggesting that the early abortion rate was higher than the late abortion rate among ACA positive pregnant women,P=0.031,which was statistically significant.5.Correlation between ACA concentration and abortion rate: 26.7% in the 12-25 RU /ml group;in the 25-35RU/ml group,the abortion rate was 44.4%;in the >35RU/ml group,the abortion rate was 75%.P = 0.042,suggesting that the higher the ACA concentration,the higher the abortion rate,and the difference was statistically significant.6.The abortion rates of the ACA-positive pregnant women and the non-intervention group were 23.3% and 46.7%,respectively.P=0.041,statistically significant,suggesting a significant reduction in abortion rate through clinical intervention.Conclusion:1.ACA positivity exists not only in pregnant women with adverse pregnancy outcomes,but also in normal pregnant women without any underlying disease;2.ACA-positive pregnant women may be more likely to miscarriage and have higher rates of early miscarriage than late miscarriage;3.The abortion rate of ACA-positive pregnant women is related to the concentration of ACA,that is,the higher the ACA concentration,the higher the abortion rate;4.ACA-positive pregnant women can improve some adverse pregnancy outcomes through intervention.