Hemostatic Effect Of Xingurgum-8 On HSP Model Animals

Objective: According to the etiology and pathogenesis of allergic purpura,combined with the theory of Mongolian medicine and current medical theory,different methods were used to establish experimental animal models,and the treatment of Mongolian medicine new safflower?8 flavor was used to better carry out Mongolian medicine.Western medicine combined with prevention and treatment of allergic purpura experimental research and clinical provide scientific reference.Methods: The animal purpura model was studied: 1 simulating the pathogenesis of the disease,using New Zealand white rabbit type ? allergic reaction,the development of experimental animal model of allergic purpura,detection of humoral immunity and cellular immunity: 2 mimic the incidence of the disease Mechanism,using type ? allergic reaction,the development of experimental animal models of allergic purpura,detection of humoral immunity and cellular immunity: 3 using Mengxi medical combination ideas to model,through the dietary antigen ovalbumin to stimulate allergic reactions,establish a high similarity Animal models,detecting humoral and cellular immunity under overall conditions.2.Model animal Xin gurgum?8 diagnosis and treatment experiment: selection of high similarity animal model New Zealand big white rabbit type ? and cellular immunity A comparative experimental study on the therapeutic effect of Xin gurgum?8 high,medium and low doses.Results 1.An animal model of allergic purpura was successfully established.2.Mongolian medicine Xin gurgum?8 can reduce the intensity of skin reaction of type ? allergic reaction in New Zealand white rabbits.3.Mongolian medicine Xin gurgum?8 New Zealand big white rabbit type ? metamorphosis caused by spleen,thymus enlargement inhibition,compared with the model group was statistically significant(P <0.01).4.Mongolian medicine Xin gurgum?8 can significantly reduce the content of IgG.IgM.c3 in serum of New Zealand white rabbit type ? allergic model(P<0.05).5.Mongolian medicine Xin gurgum?8 can reduce the content of platelets,lymphocytes and eosinophils in the blood routine of New Zealand white rabbit type ? allergic model(P<0.05),there are significant differences.6.Mongolian medicine Xin gurgum?8 can reduce the occult blood in the urine type of the New Zealand white rabbit type ? allergic model,protein content(P <0.05),there are significant differences.Conclusions: 1.New Zealand white rabbit type ? allergy can be used as an animal model of allergic purpura.2.The Xin gurgum?8 flavor can restore normal IgG in the serum.3.The Xin gurgum?8 taste changes the ratio of antigen to antibody,so that the immune alleviating the damage caused by type ? allergic reaction.4.The Xin gurgum?8 flavor original drug and capsule have remarkable effects,and have good anti?inflammatory,anti?allergic and immune?regulating effects.