Predictive Value Of Procalcitonin,White Blood Cell Count And C-reactive Protein For Kawasaki Disease With Coronary Artery Lesion

Kawasaki disease(KD)is a self-limiting vasculitic disease involving small and medium blood vessels in the body,which occurs in children.The disease was first reported in 1967 by Dr Tomisacu Kawasaki of Japan(Kawasaki Fusaku),so it was named Kawasaki disease internationally.Mainly manifested as acute fever,conjunctival hyperemia,diffuse congestion of oral mucosa and swollen lymph nodes in the neck,which occur in infants and young children.The children <5 years old account for more than 85%,and boys are more common(male: female about 1.83:1)The severity of the disease varies greatly.It is currently one of the common febrile diseases in infants under 5 years old,and may be related to infection,immune activation,cytokines,and genetic background.Some untreated or delayed KD children may progress to myocardial infarction,coronary aneurysm rupture,and thrombosis.The disease received short-term fever after intravenous immunoglobulin(IVIG)and oral aspirin(ASP)treatment within 10 days,the clinical symptoms were improved,and the incidence of CAL decreased,but some patients with incomplete Kawasaki disease still had IVIG is unresponsive,fever persists,and the risk of developing CAL increases.This study explored the clinical factors of Kawasaki disease with coronary artery lesion and related laboratory test indicators to explore the related factors of Kawasaki disease with coronary artery lesion.Objective:This article retrospectively analyzed the clinical data,laboratory indicators and echocardiographic findings of 204 children with KD diagnosed in the Department of Pediatrics,Affiliated Hospital of Chengde Medical College.The purpose was to analyze the risk factors of KD combined with CAL,so as to timely formulate effective treatment options to reduce the incidence of CAL.Methods:Affiliated Hospital of Chengde Medical College was selected from January 2014 to June 2018 in Pediatrics and was diagnosed as 204 children with Kawasaki disease.According to the diagnostic criteria of coronary artery lesions,the observation group was divided into observation group and control group.The observation group was coronary lesions,a total of 90 cases,and the control group was no coronary lesions,a total of 114 cases.There were 52 males and 38 females in the observation group.There were 62 males and 52 females in the control group.Statistical analysis was performed on the general clinical data,laboratory parameters and echocardiographic results of 204 subjects.The application value of the receiver operating characteristic(ROC)curve was evaluate.Results:1.There is a correlation between gender and Kawasaki disease with coronary artery lesion.2.There were significant differences in WBC,CRP,and PCT levels between the two groups.3.In the assessment of coronary artery lesion,the combined detection of WBC,PCT,and CRP is more predictive than single index.The area under the ROC curve is 0.876,the sensitivity is 0.900,and the specificity is 0.763.Conclusion:1.The results of this study showed that the incidence of coronary artery lesions in male KD children was higher than that in female KD children.2.The results of this study show that elevated levels of WBC,CRP,and PCT are risk factors for KD combined with CAL.3.Compared with the single indicator detection,the combined detection of WBC,CRP and PCT has higher predictive value for KD combined CAL.